Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786769 | 0.81 | KDM4E (0.46) | LMNAPOLBKDM4EALDH1A1TDP1 | |
| SCHEMBL4789084 | 0.79 | KDM4E (0.45) | LMNAKDM4EALDH1A1TDP1MEN1 | |
| SCHEMBL6819440 | 0.79 | ADRA1A (0.40) | POLBKDM4EALDH1A1ADRA1AMAPT | |
| SCHEMBL4213722 | 0.79 | ADRA1A (0.40) | POLBKDM4EALDH1A1ADRA1AMAPT | |
| SCHEMBL4787977 | 0.73 | L3MBTL1 (0.40) | LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL6823565 | 0.70 | DRD2 (0.43) | POLBKDM4EALDH1A1ADRA1AMAPT | |
| SCHEMBL6823568 | 0.70 | DRD2 (0.43) | POLBKDM4EALDH1A1ADRA1AMAPT | |
| SCHEMBL5634205 | 0.69 | LMNA (0.49) | LMNAMC4RCA2NCF1CHKA | |
| SCHEMBL4787954 | 0.68 | MEN1 (0.39) | LMNAPOLBKDM4EALDH1A1MEN1 | |
| SCHEMBL4750459 | 0.68 | LTA4H (0.41) | NR1H2LMNAPOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |