Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896089 | 0.90 | L3MBTL1 (0.46) | NPC1RAB9AL3MBTL1HTTALDH1A1 | |
| SCHEMBL3288928 | 0.81 | L3MBTL1 (0.46) | NPC1RAB9AL3MBTL1HTTALDH1A1 | |
| SCHEMBL4788680 | 0.75 | MAPT (0.45) | NPC1RAB9AL3MBTL1HTTALDH1A1 | |
| SCHEMBL3441603 | 0.71 | L3MBTL1 (0.48) | NPC1RAB9AL3MBTL1HTTALDH1A1 | |
| SCHEMBL4788013 | 0.70 | ENPP2 (0.43) | ALDH1A1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL4896320 | 0.70 | L3MBTL1 (0.54) | NPC1RAB9AL3MBTL1HTTALDH1A1 | |
| SCHEMBL4789019 | 0.70 | SMN1; SMN2 (0.41) | NPC1RAB9AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3441807 | 0.69 | L3MBTL1 (0.47) | NPC1RAB9AL3MBTL1HTTALDH1A1 | |
| SCHEMBL13923633 | 0.67 | RAB9A (0.65) | NPC1RAB9AL3MBTL1HTTALDH1A1 | |
| SCHEMBL7491132 | 0.65 | NPC1 (0.62) | NPC1RAB9AL3MBTL1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130313-A1 | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE GABA RECEPTOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |