Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4885880 | 0.88 | CNR1 (0.39) | SMN1; SMN2KDM4EADCY1EGFRERBB3 | |
| SCHEMBL4788948 | 0.85 | KMT2A (0.43) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL4891786 | 0.81 | ALDH1A1 (0.42) | SMN1; SMN2KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL4747643 | 0.80 | FFAR2 (0.44) | SMN1; SMN2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL4786538 | 0.80 | CXCR2 (0.45) | SMN1; SMN2MEN1KMT2ACASP3SENP8 | |
| SCHEMBL4786438 | 0.75 | CNR1 (0.43) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4749922 | 0.75 | KDM4E (0.45) | SMN1; SMN2KDM4EMAPTALDH1A1L3MBTL1 | |
| SCHEMBL4576546 | 0.73 | PTGS2 (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL4897158 | 0.72 | MAPT (0.41) | KDM4EMAPTALDH1A1 | |
| SCHEMBL4788013 | 0.72 | ENPP2 (0.43) | SMN1; SMN2MAPTALDH1A1MAPK1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130313-A1 | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE GABA RECEPTOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |