Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 6/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790682 | 0.86 | NPC1 (0.47) | RAB9AKMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL4718481 | 0.75 | PTGDR2 (0.38) | RAB9ANPC1ALDH1A1MAPTNAMPT | |
| SCHEMBL3710550 | 0.75 | MEN1 (0.82) | RAB9AMEN1KMT2AGAANPC1 | |
| SCHEMBL3706890 | 0.75 | RAB9A (1.00) | RAB9AMEN1KMT2AGAANPC1 | |
| SCHEMBL4790954 | 0.74 | NAMPT (0.47) | NAMPT | |
| SCHEMBL31455212 | 0.72 | ALDH1A1 (0.68) | RAB9AMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL4791291 | 0.72 | NAMPT (0.36) | NAMPT | |
| SCHEMBL14221973 | 0.71 | NAMPT (0.46) | RAB9AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL31455191 | 0.70 | GAA (0.61) | RAB9AMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL28363737 | 0.69 | GAA (0.64) | RAB9AMEN1KMT2AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |
| US-6514964-B1 | Treating diseases, conditions or disorders mediated by integrin receptors, such as vitronectin and fibronectin receptors | AMGEN INC. | 2003-02-04 | — | — | US | disclosed |