Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11380312 | 0.84 | GABRA1 (0.43) | GABRA1GABRB2AKR1B1KMT2AL3MBTL1 | |
| SCHEMBL5204636 | 0.78 | TLR8 (0.38) | ALDH1A1 | |
| SCHEMBL176260 | 0.78 | GABRA1 (0.42) | GABRA1GABRB2AKR1B1MEN1MAPT | |
| SCHEMBL9689790 | 0.76 | — | — | |
| SCHEMBL1638775 | 0.76 | GABRA1 (0.50) | GABRA1GABRB2AKR1B1MEN1MAPT | |
| SCHEMBL7761703 | 0.76 | GABRA1 (0.41) | GABRA1GABRB2AKR1B1MEN1MAPT | |
| SCHEMBL3661576 | 0.76 | GABRA1 (0.41) | GABRA1GABRB2AKR1B1MEN1MAPT | |
| SCHEMBL1515067 | 0.76 | GABRA1 (0.41) | GABRA1GABRB2AKR1B1MEN1MAPT | |
| SCHEMBL5454296 | 0.76 | GABRA1 (0.41) | GABRA1GABRB2AKR1B1MEN1MAPT | |
| SCHEMBL5091335 | 0.76 | GABRA1 (0.41) | GABRA1GABRB2AKR1B1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1913884-A | Substituted benzazoles and methods of their use as inhibitors of RAF kinase | CHIRON CORP (US) | 2007-02-14 | — | — | CN | claimed |
| CN-1655779-A | substituted indoles and their use as Raf kinase inhibitors | CHIRON CORP (US) | 2005-08-17 | — | — | CN | claimed |
| US-3941887-A | Dithiobiuret derivatives used for repelling birds, rodents, leporine animals and ruminants | BAYER AKTIENGESELLSCHAFT (DT) | 1976-03-02 | — | — | US | claimed |
| WO-2024064769-A1 | INDUCTION OF STEM-LIKE ACTIVATED T CELLS | PHIO PHARMACEUTICALS CORP. (US) | 2024-03-28 | — | — | WO | disclosed |
| EP-3980404-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | Exelixis, Inc. (US) | 2022-04-13 | — | — | EP | disclosed |
| WO-2020247418-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | EXELIXIS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |
| WO-2019079706-A1 | AMINOGLYCOSIDE ANTIBIOTICS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-04-25 | — | — | WO | disclosed |
| WO-2018213365-A1 | COMPOUNDS FOR TREATING DENGUE VIRUS INFECTION AND OTHER VIRAL INFECTIONS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-11-22 | — | — | WO | disclosed |
| EP-3092220-A1 | VITAMIN C PRODRUGS AND USES THEREOF | University of Florida Research Foundation, Inc. (US) | 2016-11-16 | — | — | EP | disclosed |
| WO-2016100444-A1 | TREATMENT OF CLOSED HEAD INJURY AND HEMORRHAGIC STROKE WITH HBED | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-06-23 | — | — | WO | disclosed |
| EP-2991665-A1 | STAPLED AND STITCHED POLYPEPTIDES AND USES THEREOF | President and Fellows of Harvard College (US) | 2016-03-09 | — | — | EP | disclosed |
| CN-101495147-B | Pharmaceutical combinations. | NOVARTIS AG | 2012-01-25 | — | — | CN | disclosed |
| CN-101495147-A | Pharmaceutical combinations. | NOVARTIS AG (CH) | 2009-07-29 | — | — | CN | disclosed |
| EP-1940835-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007036733-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |
| CN-1913884-A | Substituted benzazoles and methods of their use as inhibitors of RAF kinase | CHIRON CORP (US) | 2007-02-14 | — | — | CN | disclosed |
| EP-1737857-A1 | PYRAZOLO[3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005058892-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-30 | — | — | WO | disclosed |
| US-6245722-B1 | Silicone wax-based dry lubricant | Maples, Paul D. | 2001-06-12 | — | — | US | disclosed |
| US-3941887-A | Dithiobiuret derivatives used for repelling birds, rodents, leporine animals and ruminants | BAYER AKTIENGESELLSCHAFT (DT) | 1976-03-02 | — | — | US | disclosed |