Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 8/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1278276 | 0.96 | NAMPT (0.38) | MMP1MMP9MMP13NAMPTCHRNB4 | |
| SCHEMBL4789900 | 0.93 | MMP9 (0.32) | MMP1MMP9MMP13NAMPTCHRNB4 | |
| Fumaric Acid SCHEMBL4791584 | 0.89 | NAMPT (0.35) | MMP1MMP9MMP13NAMPTCHRNB4 | |
| SCHEMBL4792897 | 0.88 | PTGDR2 (0.33) | NAMPTCHRNB4CHRNA3ADAM17POLB | |
| SCHEMBL4791521 | 0.87 | NAMPT (0.36) | MMP1MMP9MMP13NAMPT | |
| SCHEMBL1157389 | 0.87 | PTGDR2 (0.37) | NAMPTCHRNB4CHRNA3POLB | |
| SCHEMBL1156754 | 0.86 | HSD17B10 (0.38) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL4422719 | 0.85 | PTGDR2 (0.33) | ADAM17 | |
| Carbamic Acid SCHEMBL4791644 | 0.84 | HSD17B10 (0.36) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL1278508 | 0.83 | FPR1 (0.34) | NAMPTCHRNB4CHRNA3POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919865-A1 | 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026916-A1 | 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-08 | — | — | WO | disclosed |