Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200772 | 0.81 | CES1 (0.44) | CES1SRCGAAALDH1A1MEN1 | |
| SCHEMBL6202040 | 0.80 | LMNA (0.48) | CES1SRCALDH1A1TDP1LMNA | |
| SCHEMBL6202503 | 0.80 | CES1 (0.42) | CES1SRCALDH1A1MEN1KMT2A | |
| SCHEMBL390943 | 0.79 | CES1 (0.52) | CES1SRCALDH1A1MEN1KMT2A | |
| SCHEMBL11789186 | 0.79 | CES1 (0.50) | CES1SRCALDH1A1MEN1KMT2A | |
| SCHEMBL6322308 | 0.78 | L3MBTL1 (0.46) | CES1SRCGAAALDH1A1KDM4E | |
| SCHEMBL36374 | 0.77 | CES1 (0.48) | CES1SRCALDH1A1MEN1KMT2A | |
| SCHEMBL452703 | 0.76 | CES1 (0.49) | CES1SRCGAAALDH1A1MEN1 | |
| SCHEMBL11057570 | 0.76 | CES1 (0.45) | CES1SRCALDH1A1MEN1KMT2A | |
| SCHEMBL6328600 | 0.75 | CES1 (0.47) | CES1SRCALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124575-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |