Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15676570 | 0.84 | ALDH1A1 (0.35) | TSHRALDH1A1GLA | |
| SCHEMBL5200801 | 0.73 | GRIN2D (0.35) | — | |
| SCHEMBL11662702 | 0.73 | — | — | |
| SCHEMBL3036337 | 0.71 | ALDH1A1 (0.30) | TSHRALDH1A1GLA | |
| SCHEMBL15059410 | 0.69 | POLB (0.50) | TSHRALDH1A1GLALMNASMN1; SMN2 | |
| SCHEMBL30528370 | 0.69 | POLB (0.50) | TSHRALDH1A1GLALMNASMN1; SMN2 | |
| SCHEMBL1998465 | 0.68 | — | — | |
| SCHEMBL9341830 | 0.66 | — | — | |
| SCHEMBL16448086 | 0.66 | TAAR1 (0.35) | TSHRALDH1A1GLAKDM4ESMN1; SMN2 | |
| SCHEMBL11522975 | 0.65 | LMNA (0.31) | TSHRALDH1A1LMNAPAX8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976828-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | Schering Aktiengesellschaft (DE) | 2008-10-08 | — | — | EP | claimed |
| WO-2007079078-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | claimed |
| CN-100422161-C | Hydroxymorpholinone derivative and medicinal use thereof | SENJU PHARMA CO (JP) | 2008-10-01 | — | — | CN | disclosed |
| CN-1656084-A | Hydroxymorpholone derivative and medical application thereof | SENJU PHARMA CO (JP) | 2005-08-17 | — | — | CN | disclosed |