Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 9/20 | 0.71 |
| ▸ | GRN | P28799 | 2/20 | 0.63 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.63 |
| ▸ | CTSS | P25774 | 8/20 | 0.60 |
| ▸ | CTSK | P43235 | 8/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4159712 | 1.00 | CTSL (0.71) | CTSLGRNSORT1CTSSCTSK | |
| SCHEMBL4206948 | 0.86 | TAS1R3 (0.75) | CTSLCTSSCTSKTAS1R3TAS1R1 | |
| SCHEMBL4206947 | 0.86 | TAS1R3 (0.75) | CTSLCTSSCTSKTAS1R3TAS1R1 | |
| SCHEMBL9831840 | 0.85 | TAS1R3 (0.58) | CTSLCTSSCTSKATMTAS1R3 | |
| SCHEMBL9831838 | 0.85 | TAS1R3 (0.58) | CTSLCTSSCTSKATMTAS1R3 | |
| SCHEMBL4465251 | 0.85 | CTSL (0.67) | CTSLGRNSORT1CTSSCTSK | |
| SCHEMBL2158900 | 0.85 | CTSL (0.67) | CTSLGRNSORT1CTSSCTSK | |
| SCHEMBL2158906 | 0.85 | CTSL (0.67) | CTSLGRNSORT1CTSSCTSK | |
| SCHEMBL24283517 | 0.84 | GRN (0.74) | CTSLGRNSORT1CTSSCTSK | |
| SCHEMBL24283516 | 0.84 | GRN (0.74) | CTSLGRNSORT1CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2008-10-02 | — | — | US | disclosed |
| US-7384970-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2008-06-10 | — | — | US | disclosed |
| US-20040248887-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2004-12-09 | — | — | US | disclosed |
| WO-2004084843-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248887-A1 | Inhibitors of cathepsin S | CTSS, CTSB, CTSZ | CTSL 11/4885GRN 606/4885SORT1 243/4885 |
| US-20080242671-A1 | INHIBITORS OF CATHEPSIN S | CTSS, CTSB, CTSZ | CTSL 11/4885GRN 606/4885SORT1 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.