Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732492 | 0.72 | MAPT (0.52) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL8346599 | 0.70 | FGFR1 (0.60) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL8525187 | 0.68 | POLB (0.57) | ALDH1A1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL30441533 | 0.67 | FGFR1 (0.70) | ALDH1A1RAB9AMEN1KMT2APOLB | |
| SCHEMBL27856677 | 0.66 | MAPT (0.48) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL24416411 | 0.66 | BRD4 (0.44) | ALDH1A1RAB9APOLBHTT | |
| SCHEMBL27908151 | 0.66 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL165760 | 0.66 | TSHR (0.62) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL3341971 | 0.65 | CA12 (0.50) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL11491739 | 0.65 | MAPT (0.67) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |