Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28033810 | 0.82 | MAPT (0.47) | MAPTKMT2AKCNN4CYP1A2CYP2D6 | |
| SCHEMBL5617129 | 0.71 | KIF11 (0.44) | MAPTKMT2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL2964988 | 0.71 | GABRA1 (0.45) | GABRA1GABRB2MAPTCYP1A2ALDH1A1 | |
| SCHEMBL6529359 | 0.70 | MAPT (0.48) | MAPTKMT2AKCNN4CYP1A2CYP2D6 | |
| SCHEMBL984514 | 0.70 | GABRA1 (0.41) | GABRA1GABRB2MAPTKMT2ACASP1 | |
| SCHEMBL4334002 | 0.70 | HTT (0.38) | MAPTKMT2ACYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL28253160 | 0.70 | CYP2C19 (0.40) | GABRA1GABRB2MAPTKMT2AKCNN4 | |
| SCHEMBL12238626 | 0.69 | GABRA1 (0.43) | GABRA1GABRB2MAPTKMT2ACYP2D6 | |
| SCHEMBL20293767 | 0.69 | MAPT (0.47) | MAPTKMT2AKCNN4CYP1A2CYP2D6 | |
| SCHEMBL27586113 | 0.69 | GABRA1 (0.39) | GABRA1GABRB2MAPTKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016676-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |