Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27837868 | 0.88 | SMN1; SMN2 (0.39) | CTSKMAPTKMT2ACYP3A4CYP2C19 | |
| SCHEMBL27737954 | 0.88 | CYP4F2 (0.41) | CTSKMAPTKMT2ACYP3A4CYP2C19 | |
| SCHEMBL27758897 | 0.87 | CTSK (0.35) | CTSKMAPTKMT2ACYP3A4CYP2C19 | |
| SCHEMBL27839098 | 0.87 | CTSK (0.35) | CTSKMAPTKMT2ACYP3A4CYP2C19 | |
| SCHEMBL28272597 | 0.85 | NR3C2 (0.43) | CTSKKMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL27500366 | 0.85 | FDPS (0.46) | CTSKMAPTKMT2ACYP3A4CYP2C19 | |
| SCHEMBL27852818 | 0.83 | RIPK1 (0.43) | CTSKMAPTKMT2ALMNARIPK1 | |
| SCHEMBL27668919 | 0.83 | ALDH1A1 (0.47) | CTSKKMT2ALMNARIPK1KDM4E | |
| SCHEMBL28183309 | 0.83 | L3MBTL1 (0.47) | MAPTKMT2ACYP1A2CYP2C9LMNA | |
| SCHEMBL3656311 | 0.79 | SMN1; SMN2 (0.48) | CTSKMAPTKMT2ACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101657432-B | Dihydro-benzo[B][1,4]diazepin-2-one sulfonamide derivatives | HOFFMANN LA ROCHE CH | 2013-04-10 | — | — | CN | disclosed |
| CN-101657432-A | Dihydro-benzo [B] [1,4] diaza-2-ketone sulfonamide derivs | HOFFMANN LA ROCHE CH | 2010-02-24 | — | — | CN | disclosed |
| CN-1535266-A | Dihydro-benzo [b][1,4] diazepin-2-one derivatives as mglur 2 antagonists II | - | 2004-10-06 | — | — | CN | disclosed |