Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9610044 | 0.81 | MPO (0.52) | ALDH1A1L3MBTL1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL7885609 | 0.79 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1KDM4EPARP10KMT2A | |
| SCHEMBL11182181 | 0.76 | TGM2 (0.36) | ALDH1A1L3MBTL1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL16388314 | 0.76 | F2 (0.46) | ALDH1A1L3MBTL1KDM4EPARP10KMT2A | |
| SCHEMBL10416379 | 0.74 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KMT2ASMN1; SMN2MAPT | |
| Terephthalamide SCHEMBL28465832 | 0.74 | PARP10 (0.48) | ALDH1A1L3MBTL1PARP10KMT2APARP4 | |
| SCHEMBL8989664 | 0.74 | ALDH5A1 (0.42) | ALDH1A1L3MBTL1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL6727924 | 0.74 | MAPT (0.43) | ALDH1A1L3MBTL1KDM4EKMT2ASMN1; SMN2 | |
| Terephthalamide SCHEMBL23774 | 0.72 | PARP1 (0.71) | ALDH1A1L3MBTL1PARP10KMT2APARP4 | |
| SCHEMBL9785812 | 0.72 | SMN1; SMN2 (0.57) | ALDH1A1L3MBTL1KDM4EKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | D SIDOCKY NEIL R | 2008-10-02 | — | — | US | disclosed |
| WO-2008036308-A2 | AMINO-SUBSTITUTED HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | JAK2, CHEK2, MTOR | ALDH1A1 1752/4885L3MBTL1 1483/4885KDM4E 1212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.