Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.45 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12592838 | 0.86 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1PARP10KMT2APARP4 | |
| SCHEMBL15453215 | 0.82 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL4532711 | 0.82 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1KMT2AKDM4EMAPT | |
| SCHEMBL7440442 | 0.81 | PRSS1 (0.57) | ALDH1A1HSD17B10CYP2C19F2PRSS1 | |
| SCHEMBL1086165 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KMT2AKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL4795623 | 0.79 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1PARP10KMT2APARP4 | |
| SCHEMBL1086084 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KMT2AKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL3691518 | 0.78 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1PARP10KMT2APARP15 | |
| SCHEMBL14705725 | 0.78 | PEPD (0.59) | ALDH1A1KMT2AMAPTHSD17B10CA2 | |
| SCHEMBL1555352 | 0.78 | MAPT (0.54) | ALDH1A1L3MBTL1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912574-A1 | BETA-LACTAMS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-06 | — | — | EP | claimed |
| WO-1997045429-A1 | BETA-LACTAMS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-04 | — | — | WO | claimed |
| US-5494666-A | BETA-LACTAMASE INHIBITORS, ANTIBACTERIALS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | claimed |
| US-5464617-A | 1H-2,6a-diazacyclobut(cd)indene-6-carboxylic acid derivatives, antibiotics | HOFFMANN-LA ROCHE INC. (US) | 1995-11-07 | — | — | US | claimed |
| US-20230348441-A1 | BICYCLIC COMPOUND THAT ACTS AS CRBN PROTEIN REGULATOR | MEDSHINE DISCOVERY INC. (CN) | 2023-11-02 | — | — | US | disclosed |
| CN-112125828-B | Synthetic method of foramsulfuron intermediate | 江苏省农用激素工程技术研究中心有限公司 | 2022-05-06 | — | — | CN | disclosed |
| WO-2021047674-A1 | BICYCLIC COMPOUND THAT ACTS AS CRBN PROTEIN REGULATOR | 南京明德新药研发有限公司 | 2021-03-18 | — | — | WO | disclosed |
| CN-105670340-B | Preparation method of C.I. pigment yellow 180 | 上虞市新利化工有限公司 | 2017-05-03 | — | — | CN | disclosed |
| CN-100500654-C | Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCRs) | ZENTARIS AG (DE) | 2009-06-17 | — | — | CN | disclosed |
| US-20070232654-A1 | Novel Compounds and Compositions as Cathepsin Inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2007-10-04 | — | — | US | disclosed |
| CN-1599720-A | Tetrahydrocarbazole derivatives as ligands for G-protein coupled receptors (GPCRs) | ZENTARIS AG (DE) | 2005-03-23 | — | — | CN | disclosed |
| US-6218379-B1 | Tricyclic carbacephems | HOFFMANN-LA ROCHE INC. | 2001-04-17 | — | — | US | disclosed |
| US-5633282-A | ENZYME INHIBITORS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-05-27 | — | — | US | disclosed |
| EP-0531370-B1 | INHIBITION OF VIRAL INFECTION | BRITISH TECH GROUP (GB) | 1996-09-18 | — | — | EP | disclosed |
| US-5494666-A | BETA-LACTAMASE INHIBITORS, ANTIBACTERIALS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| US-5464617-A | 1H-2,6a-diazacyclobut(cd)indene-6-carboxylic acid derivatives, antibiotics | HOFFMANN-LA ROCHE INC. (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0671401-A1 | Beta lactames | F. HOFFMANN-LA ROCHE AG (CH) | 1995-09-13 | — | — | EP | disclosed |
| EP-0531370-A1 | INHIBITION OF VIRAL INFECTION. | COLLINS MARY KATHARINE LEVINGE (GB) | 1993-03-17 | — | — | EP | disclosed |
| WO-1991018591-A1 | INHIBITION OF VIRAL INFECTION | COLLINS MARY KATHARINE LEVINGE (GB) | 1991-12-12 | — | — | WO | disclosed |
| US-5026831-A | Water-insoluble disazo colorants having hetero-bicyclic methylene-active compounds as coupling component | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348441-A1 | BICYCLIC COMPOUND THAT ACTS AS CRBN PROTEIN REGULATOR | CRBN, CRKL, NCOR1 | ALDH1A1 4261/4885L3MBTL1 4032/4885PARP10 3256/4885 |
| US-20070232654-A1 | Novel Compounds and Compositions as Cathepsin Inhibitors | CTSS, CTSB, CTSE | ALDH1A1 4046/4885L3MBTL1 4113/4885PARP10 2228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.