Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782463 | 0.90 | OPRM1 (0.44) | CHRNB4CHRNA3OPRM1OPRD1OPRK1 | |
| SCHEMBL4780323 | 0.88 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL8220685 | 0.88 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL4781846 | 0.86 | DPP4 (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL4776087 | 0.85 | ROCK2 (0.42) | ROCK2ROCK1CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL4776097 | 0.85 | ROCK2 (0.42) | ROCK2ROCK1CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL4795928 | 0.82 | HTR1A (0.39) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4795980 | 0.78 | CHRNB4 (0.48) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL4776986 | 0.78 | CHRNB4 (0.46) | CHRNB4CHRNA3OPRM1OPRD1OPRK1 | |
| SCHEMBL4776989 | 0.78 | CHRNB4 (0.46) | CHRNB4CHRNA3OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008018639-A2 | GLYCINE TRANSPORTER INHIBITOR | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-02-14 | — | — | WO | disclosed |
| WO-2008018639-A2 | GLYCINE TRANSPORTER INHIBITOR | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-02-14 | — | — | WO | disclosed |