Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4797971 | 0.84 | KDM4E (0.44) | MAPTNPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL4795138 | 0.83 | RAB9A (0.46) | MAPTNPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL4797498 | 0.82 | KDM4E (0.42) | MAPTNPC1RAB9AHTTGAA | |
| SCHEMBL3339390 | 0.79 | GAA (0.47) | MAPTNPC1RAB9AHTTTP53 | |
| SCHEMBL4797913 | 0.75 | HSD17B10 (0.44) | MAPTNPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL4794786 | 0.68 | KMT2A (0.68) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL19719044 | 0.68 | RAB9A (0.64) | MAPTNPC1RAB9ASMN1; SMN2XDH | |
| SCHEMBL7894108 | 0.66 | ADORA3 (0.66) | MAPTNPC1RAB9AHTTTP53 | |
| SCHEMBL4797456 | 0.66 | GRM1 (0.48) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL4797632 | 0.65 | KMT2A (0.74) | MAPTNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | claimed |
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |