Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802225 | 0.86 | KMT2A (0.41) | HTR2CSMN1; SMN2ALDH1A1HTTHTR2A | |
| SCHEMBL4795055 | 0.85 | KMT2A (0.39) | HTR2CSMN1; SMN2ALDH1A1HTR2A | |
| SCHEMBL4798089 | 0.74 | ALDH1A1 (0.37) | SMN1; SMN2NAMPTALDH1A1 | |
| SCHEMBL4732243 | 0.73 | CNR2 (0.39) | ALDH1A1HTT | |
| SCHEMBL4730155 | 0.72 | CNR2 (0.39) | HTT | |
| SCHEMBL4732586 | 0.69 | HTT (0.38) | SMN1; SMN2ALDH1A1HPGDHTT | |
| SCHEMBL4802221 | 0.69 | ALDH1A1 (0.38) | HTR2BMAPK1SMN1; SMN2KCNH2ALDH1A1 | |
| SCHEMBL4732186 | 0.68 | HTT (0.36) | ALDH1A1HTT | |
| SCHEMBL4795053 | 0.67 | ALDH1A1 (0.38) | HTR2BMAPK1SMN1; SMN2KCNH2ALDH1A1 | |
| SCHEMBL4730085 | 0.66 | KMT2A (0.41) | SMN1; SMN2KCNH2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |