Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.38 |
| ▸ | HTR6 | P50406 | 6/20 | 0.38 |
| ▸ | HTR1A | P08908 | 10/20 | 0.36 |
| ▸ | HTR7 | P34969 | 10/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | WNT3 | P56703 | 1/20 | 0.34 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732227 | 0.77 | HTR1A (0.38) | DRD2HTR6HTR1AHTR7ALOX5AP | |
| SCHEMBL4730358 | 0.73 | BRD4 (0.39) | DRD2HTR6HTR1AHTR7ALOX5AP | |
| SCHEMBL4799706 | 0.71 | SLC6A2 (0.31) | — | |
| SCHEMBL4729713 | 0.70 | HTR1A (0.36) | DRD2HTR6HTR1AHTR7ALOX5AP | |
| SCHEMBL4734290 | 0.69 | HTR1A (0.35) | DRD2HTR6HTR1AHTR7ALOX5AP | |
| SCHEMBL4734388 | 0.66 | CCR8 (0.46) | DRD2HTR6HTR1AHTR7ALOX5AP | |
| Hydrochloric Acid SCHEMBL4734829 | 0.65 | CCR8 (0.46) | DRD2HTR6HTR1AHTR7ALOX5AP | |
| SCHEMBL4617906 | 0.64 | SFRP1 (0.56) | DRD2HTR6HTR1AHTR7WNT3 | |
| SCHEMBL4735405 | 0.63 | HTR1A (0.39) | DRD2HTR6HTR1AHTR7ADRA1D | |
| SCHEMBL6102370 | 0.63 | SFRP1 (0.66) | WNT3SFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |