Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.39 |
| ▸ | HTR1A | P08908 | 5/20 | 0.36 |
| ▸ | HTR7 | P34969 | 5/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732227 | 0.90 | HTR1A (0.38) | BRD4HTR1AHTR7DRD2HTR6 | |
| SCHEMBL4734290 | 0.81 | HTR1A (0.35) | BRD4HTR1AHTR7DRD2HTR6 | |
| SCHEMBL4729713 | 0.75 | HTR1A (0.36) | BRD4HTR1AHTR7DRD2HTR6 | |
| SCHEMBL4799712 | 0.73 | DRD2 (0.38) | BRD4HTR1AHTR7DRD2HTR6 | |
| SCHEMBL4733337 | 0.72 | HTR1A (0.35) | BRD4HTR1AHTR7DRD2HTR6 | |
| SCHEMBL4734123 | 0.71 | HTR1A (0.38) | HTR1AHTR7DRD2HTR6ADRA1D | |
| SCHEMBL4735405 | 0.69 | HTR1A (0.39) | HTR1AHTR7DRD2HTR6ADRA1D | |
| SCHEMBL4731657 | 0.67 | HTR1A (0.38) | HTR1AHTR7DRD2HTR6ADRA1D | |
| SCHEMBL4617906 | 0.66 | SFRP1 (0.56) | BRD4HTR1AHTR7DRD2HTR6 | |
| SCHEMBL4782344 | 0.66 | HTR1A (0.37) | HTR1AHTR7DRD2HTR6ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |