Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731657 | 0.91 | HTR1A (0.38) | HTR1AHTR7DRD2HTR6HDAC8 | |
| SCHEMBL4736402 | 0.88 | HTR1A (0.38) | HTR1AHTR7DRD2HTR6HDAC8 | |
| SCHEMBL4733452 | 0.79 | CNR2 (0.39) | HTR1AHTR7DRD2HTR6TP53 | |
| SCHEMBL4729713 | 0.78 | HTR1A (0.36) | HTR1AHTR7DRD2HTR6HDAC8 | |
| SCHEMBL4730503 | 0.78 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2KMT2APTGDR2ALDH1A1 | |
| SCHEMBL4732339 | 0.78 | NAMPT (0.38) | — | |
| SCHEMBL4732619 | 0.77 | TAAR1 (0.43) | TP53LMNAHTTNPSR1SMN1; SMN2 | |
| SCHEMBL4782344 | 0.76 | HTR1A (0.37) | HTR1AHTR7DRD2HTR6HDAC8 | |
| SCHEMBL4732698 | 0.76 | GSTO1 (0.38) | HDAC8DPP4KCNH2DPP7LMNA | |
| SCHEMBL4730634 | 0.76 | WNT3 (0.37) | HDAC8DPP4KCNH2DPP7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |