Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | ATP4A | P20648 | 1/20 | 0.35 |
| ▸ | ATP4B | P51164 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17893848 | 0.86 | ALDH1A1 (0.48) | HSP90AA1HSP90AB1HCAR1ALDH1A1TDP1 | |
| SCHEMBL22732231 | 0.84 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1PI4KAPI4K2BPI4K2A | |
| SCHEMBL13180099 | 0.74 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1PI4KAPI4K2BPI4K2A | |
| SCHEMBL28072949 | 0.71 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1PI4KAPI4K2BPI4K2A | |
| SCHEMBL28073056 | 0.71 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1PI4KAPI4K2BPI4K2A | |
| SCHEMBL30349922 | 0.70 | ALDH1A1 (0.44) | HCAR1ALDH1A1TDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10870363 | 0.70 | RAB9A (0.34) | ALDH1A1TDP1KMT2ARAB9ACYP1A2 | |
| SCHEMBL13145112 | 0.69 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1PI4KAPI4K2BPI4K2A | |
| SCHEMBL30350059 | 0.69 | CYP11B2 (0.52) | ALDH1A1TDP1KMT2AKDM4EMAPT | |
| SCHEMBL19825146 | 0.68 | HSD11B1 (0.53) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427616-B2 | Condensed pyridines and pyrimidines with tie2 (TEK) activity | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | disclosed |
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256140-A1 | Condensed pyridines and pyrimidines with tie2 (tek) activity | TIE1, TEK, KDR | HSP90AA1 3063/4885HSP90AB1 3114/4885PI4KA 3348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.