Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507135 | 0.84 | PLAU (0.54) | ALDH1A1HPGDPLAULMNAPOLB | |
| SCHEMBL2396852 | 0.83 | ALDH1A1 (0.63) | ALDH1A1HPGDGAARAB9AMEN1 | |
| SCHEMBL31680675 | 0.77 | TRPV1 (0.64) | NQO2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6101638 | 0.77 | NQO2 (0.51) | RXFP1ALDH1A1HPGDPOLBNQO2 | |
| SCHEMBL487254 | 0.77 | TRPV1 (0.64) | NQO2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL2880191 | 0.77 | LMNA (0.54) | RXFP1ALDH1A1HPGDMETAP1LMNA | |
| SCHEMBL3246360 | 0.76 | TRPV1 (0.63) | ALDH1A1LMNAKMT2AKDM4ETRPV1 | |
| SCHEMBL421016 | 0.76 | MAPK14 (0.47) | RXFP1ALDH1A1HPGDPLAUPOLB | |
| SCHEMBL30077817 | 0.76 | RXFP1 (0.46) | RXFP1ALDH1A1HPGDPLAULMNA | |
| SCHEMBL3729968 | 0.76 | ALDH1A1 (0.45) | RXFP1ALDH1A1HPGDPLAUNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124518-A1 | OXO-DIHYDROISOINDOLE SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-16 | — | — | WO | disclosed |