Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4805760 | 1.00 | NFKB1 (0.33) | NFKB1NFKB2RELASMN1; SMN2EPHX2 | |
| SCHEMBL4803335 | 0.87 | L3MBTL1 (0.40) | SMN1; SMN2EPHX2PPARGALDH1A1LMNA | |
| SCHEMBL4803342 | 0.87 | L3MBTL1 (0.40) | SMN1; SMN2EPHX2PPARGALDH1A1LMNA | |
| SCHEMBL4804601 | 0.84 | EPHX2 (0.35) | SMN1; SMN2EPHX2PPARGALDH1A1LMNA | |
| SCHEMBL4804598 | 0.84 | EPHX2 (0.35) | SMN1; SMN2EPHX2PPARGALDH1A1LMNA | |
| SCHEMBL12333128 | 0.81 | NFKB1 (0.38) | NFKB1NFKB2RELASMN1; SMN2EPHX2 | |
| SCHEMBL8278768 | 0.79 | MEN1 (0.33) | MEN1KMT2AGAACA2HDAC1 | |
| SCHEMBL21818970 | 0.78 | CA2 (0.38) | NFKB1NFKB2RELASMN1; SMN2MEN1 | |
| SCHEMBL4612254 | 0.78 | TDP1 (0.34) | SMN1; SMN2EPHX2PPARGALDH1A1LMNA | |
| SCHEMBL1912646 | 0.78 | CA12 (0.36) | NFKB1NFKB2RELASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326794-B2 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis | LES LABORATOIRES SERVIER (FR) | 2008-02-05 | — | — | US | disclosed |
| US-7279595-B2 | Process for the preparation of high purity perindopril | LES LABORATOIRES SERVIER (FR) | 2007-10-09 | — | — | US | disclosed |
| US-20070197821-A1 | Process for the preparation of high purity perindopril | LES LABORATOIRES SERVIER (FR) | 2007-08-23 | — | — | US | disclosed |
| EP-1333026-B1 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis | SERVIER LAB (FR) | 2007-06-27 | — | — | EP | disclosed |
| US-20050119492-A1 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis | LES LABORATOIRES SERVIER (FR) | 2005-06-02 | — | — | US | disclosed |
| WO-2003064388-A2 | PROCESS FOR THE PREPARATION OF HIGH PURITY PERINDOPRIL AND INTERMEDIATES USEFUL IN THE SYNTHESIS | LES LABORATOIRES SERVIER (FR) | 2003-08-07 | — | — | WO | disclosed |
| EP-1333026-A1 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis | Les Laboratoires Servier (FR) | 2003-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197821-A1 | Process for the preparation of high purity perindopril | ACE, AGTR1, ACE2 | NFKB1 574/4885NFKB2 1038/4885RELA 1359/4885 |
| US-20050119492-A1 | Process for the preparation of high purity perindopril and intermediates useful in the synthesis | ACE, AGTR1, ACE2 | NFKB1 764/4885NFKB2 1243/4885RELA 1958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.