Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9074445 | 0.80 | PTGS2 (0.36) | HSD17B10GABRA5GABRB2MAPTRAB9A | |
| SCHEMBL7966389 | 0.80 | HSD17B10 (0.40) | HSD17B10GABRA5GABRB2ALDH1A1MEN1 | |
| SCHEMBL28111505 | 0.79 | GABRA5 (0.60) | HSD17B10GABRA5GABRB2ALDH1A1MEN1 | |
| SCHEMBL4809888 | 0.79 | MAPT (0.39) | ALDH1A1MEN1MAPTKMT2ANPC1 | |
| SCHEMBL9076762 | 0.78 | ALDH1A1 (0.52) | HSD17B10ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL4809411 | 0.76 | KDM4E (0.40) | PLAUKDM4EPI4KBPTGS2 | |
| SCHEMBL27851069 | 0.76 | HSD17B10 (0.47) | HSD17B10GABRA5GABRB2ALDH1A1MEN1 | |
| SCHEMBL10777149 | 0.74 | SMN1; SMN2 (0.42) | HSD17B10GABRA5GABRB2ALDH1A1MEN1 | |
| SCHEMBL7122988 | 0.73 | CDK5 (0.53) | ALDH1A1MAPTNPC1RAB9AKDM4E | |
| SCHEMBL2642803 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58131975-A | — | — | None | — | — | JP | disclosed |
| JP-52083836-A | — | — | None | — | — | JP | disclosed |
| US-7381734-B2 | Serine protease inhibitors | TULARIK LIMITED (GB) | 2008-06-03 | — | — | US | disclosed |
| US-7067516-B2 | Serine protease inhibitors | TULARIK LIMITED (GB) | 2006-06-27 | — | — | US | disclosed |
| US-20050267173-A1 | Serine protease inhibitors | LIVELY SARAH E | 2005-12-01 | — | — | US | disclosed |
| US-20040116439-A1 | Serine protease inhibitors | TULARIK LIMITED (GB) | 2004-06-17 | — | — | US | disclosed |
| EP-1343561-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2003-09-17 | — | — | EP | disclosed |
| EP-1294691-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2002047762-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2002-06-20 | — | — | WO | disclosed |
| WO-2001096305-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2001-12-20 | — | — | WO | disclosed |
| US-4912212-A | Cephem compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-03-27 | — | — | US | disclosed |
| US-4668783-A | Thiazolylacetamido cephalosporin compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-05-26 | — | — | US | disclosed |
| US-4514565-A | Thiazolylacetamido cephalosphorin compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-04-30 | — | — | US | disclosed |
| JP-S58131975-A | 2-AMINOTHIAZOL-4-YLGLYCINE DERIVATIVE | TAKEDA CHEM IND LTD | 1983-08-06 | — | — | JP | disclosed |
| US-4355160-A | Thiazolylacetamido cephalosporin type compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-10-19 | — | — | US | disclosed |
| US-4298606-A | Thiazolylacetamido compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-11-03 | — | — | US | disclosed |
| US-4205180-A | CHEMICAL INTERMEDIATES FOR NOVEL CEPHALOSPORIN COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-05-27 | — | — | US | disclosed |
| US-4203899-A | Thiazolylacetamido compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-05-20 | — | — | US | disclosed |
| US-4098888-A | THIAZOLYLACETAMIDO CEPHALOSPORIN TYPE COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1978-07-04 | — | — | US | disclosed |
| JP-S5283836-A | 2-AMINOTHIAZOLE-4-YL GLYCINE DERIVATIVES | TAKEDA CHEM IND LTD | 1977-07-13 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267173-A1 | Serine protease inhibitors | PRSS1, TPSAB1, CMA1 | HSD17B10 3317/4885GABRA5 4723/4885GABRB2 4805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.