Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20292477 | 0.82 | TSPO (0.45) | TSPOLMNATP53ALOX15SMN1; SMN2 | |
| SCHEMBL10827651 | 0.80 | GLI1 (0.34) | — | |
| SCHEMBL12296371 | 0.77 | MCL1 (0.45) | TSPOLMNATP53ALOX15SMN1; SMN2 | |
| SCHEMBL15657471 | 0.74 | MKNK1 (0.32) | SMN1; SMN2 | |
| SCHEMBL14173702 | 0.72 | ALDH1A1 (0.47) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL1835404 | 0.71 | MCL1 (0.36) | — | |
| SCHEMBL415873 | 0.71 | TSPO (0.37) | TSPOLMNATP53ALOX15SMN1; SMN2 | |
| SCHEMBL416854 | 0.71 | TLR4 (0.55) | TSPOLMNATP53ALOX15SMN1; SMN2 | |
| SCHEMBL25626839 | 0.70 | BRD4 (0.38) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL15475264 | 0.69 | THRB (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411362-A2 | INDOLE DERIVATIVES | GE Healthcare UK Limited (GB) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109007-A2 | INDOLE DERIVATIVES | GE HEALTHCARE LIMITED (GB) | 2010-09-30 | — | — | WO | disclosed |