Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864679 | 0.94 | MAPK1 (0.41) | THRBCYP1A2HIF1AMAPK1TSHR | |
| SCHEMBL11215361 | 0.93 | KDM4E (0.40) | CYP1A2HIF1AMAPK1TSHRL3MBTL1 | |
| SCHEMBL11373890 | 0.81 | THRB (0.36) | THRBCYP1A2HIF1AMAPK1KMT2A | |
| SCHEMBL14173702 | 0.80 | ALDH1A1 (0.47) | KMT2ABRD4KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL374935 | 0.80 | MAPK1 (0.47) | THRBCYP1A2HIF1AMAPK1KDM4E | |
| SCHEMBL31276435 | 0.80 | MAPK1 (0.47) | THRBCYP1A2HIF1AMAPK1KDM4E | |
| SCHEMBL25061 | 0.80 | MAPK1 (0.47) | THRBCYP1A2HIF1AMAPK1KDM4E | |
| SCHEMBL31198171 | 0.78 | MAPK1 (0.46) | THRBCYP1A2HIF1AMAPK1KDM4E | |
| SCHEMBL15657471 | 0.78 | MKNK1 (0.32) | THRBMAPK1 | |
| SCHEMBL1835404 | 0.75 | MCL1 (0.36) | L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2703381-B1 | METHOD FOR PRODUCING FIVE-MEMBERED RING-CONTAINING COMPOUND | ONO PHARMACEUTICAL CO (JP) | 2015-10-21 | — | — | EP | disclosed |
| US-8716500-B2 | Method for producing five-membered ring-containing compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-05-06 | — | — | US | disclosed |
| EP-2703381-A1 | METHOD FOR PRODUCING FIVE-MEMBERED RING-CONTAINING COMPOUND | Ono Pharmaceutical Co., Ltd. (JP) | 2014-03-05 | — | — | EP | disclosed |
| US-20140051874-A1 | METHOD FOR PRODUCING FIVE-MEMBERED RING-CONTAINING COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051874-A1 | METHOD FOR PRODUCING FIVE-MEMBERED RING-CONTAINING COMPOUND | PTGIS, ALOX5, PTGES | THRB 4696/4885CYP1A2 111/4885HIF1A 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.