Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 3/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30105384 | 0.83 | LOXL2 (0.60) | LOXL2AHRIDO1PCSK9 | |
| SCHEMBL3193871 | 0.83 | LOXL2 (0.60) | LOXL2AHRIDO1PCSK9 | |
| SCHEMBL28338445 | 0.82 | LOXL2 (0.69) | LOXL2AHRPCSK9HRH3 | |
| SCHEMBL401081 | 0.82 | LOXL2 (0.69) | LOXL2AHRPCSK9HRH3 | |
| SCHEMBL29403791 | 0.82 | LOXL2 (0.69) | LOXL2AHRPCSK9HRH3 | |
| Hydrochloric Acid SCHEMBL27754931 | 0.81 | LOXL2 (0.58) | LOXL2AHRIDO1 | |
| Bromide SCHEMBL30437340 | 0.81 | LOXL2 (0.58) | LOXL2AHRIDO1PCSK9 | |
| SCHEMBL7494967 | 0.81 | PCSK9 (0.50) | LOXL2AHRPCSK9 | |
| SCHEMBL3260101 | 0.81 | DRD2 (0.49) | — | |
| SCHEMBL3262489 | 0.81 | RAB9A (0.48) | LOXL2AHRIDO1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |