SCHEMBL4807982

SCHEMBL4807982

BrC(Br)C(Br)C(Br)C(Br)C(Br)C(Br)(c1ccccc1)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 3/20 0.33
TSHR P16473 2/20 0.33
ALDH1A1 P00352 1/20 0.33
KIF11 P52732 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4811564 0.98 KCNN4 (0.35) KCNN4TSHRALDH1A1KIF11MAPK1
SCHEMBL5650092 0.80 KIF11 (0.39) KCNN4TSHRALDH1A1KIF11MAPK1
SCHEMBL4813380 0.78 TSHR (0.31) KCNN4TSHRALDH1A1
SCHEMBL4810684 0.71 TSHR (0.32) KCNN4TSHRALDH1A1
SCHEMBL651122 0.69 ALDH1A1 (0.43) KCNN4TSHRALDH1A1MAPK1
SCHEMBL4814452 0.68 TSHR (0.30) KCNN4TSHRALDH1A1
SCHEMBL4808940 0.67 CES2 (0.39) TSHR
SCHEMBL6050021 0.65 KCNN4 (0.46) KCNN4TSHRALDH1A1MAPK1
SCHEMBL4814615 0.65 KCNN4 (0.35) KCNN4TSHRALDH1A1MAPK1
SCHEMBL5968382 0.64 CES2 (0.41) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7405254-B2 Brominated anionic styrenic polymer, and decabromodiphenylpropane or decabromodiphenylethane ALBEMARLE CORPORATION (US) 2008-07-29 US disclosed
EP-1711555-B1 FLAME RETARDANT COMPOSITIONS AND THEIR USE ALBEMARLE CORP (US) 2008-07-09 EP disclosed
US-20070117904-A1 Flame Retardant Compositions and Their Use ALBEMARLE CORPORATION (US) 2007-05-24 US disclosed
US-7202296-B2 Flame retardant compositions and their use ALBEMARLE CORPORATION (US) 2007-04-10 US disclosed
EP-1711555-A1 FLAME RETARDANT COMPOSITIONS AND THEIR USE ALBEMARLE CORPORATION (US) 2006-10-18 EP disclosed
WO-2005063869-A1 FLAME RETARDANT COMPOSITIONS AND THEIR USE ALBEMARLE CORPORATION (US) 2005-07-14 WO disclosed
US-20050137311-A1 Flame retardant compositions and their use ALBEMARLE CORPORATION 2005-06-23 US disclosed