Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.57 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2433695 | 0.92 | CHRNB2 (0.56) | CHRNB2CHRNA7CHRNA4CHRNA5KDM4E | |
| SCHEMBL5681974 | 0.89 | CHRNB2 (0.52) | CHRNB2CHRNA7CHRNA4CHRNA5EGFR | |
| SCHEMBL4815476 | 0.86 | CHRNB2 (0.58) | CHRNB2CHRNA7CHRNA4CHRNA5EGFR | |
| SCHEMBL3570241 | 0.84 | GAA (0.45) | CHRNB2CHRNA7CHRNA4CHRNA5L3MBTL1 | |
| SCHEMBL7370844 | 0.78 | SMN1; SMN2 (0.55) | L3MBTL1KDM4ELMNANPC1MAPK1 | |
| SCHEMBL2438025 | 0.76 | CHRNB2 (0.57) | CHRNB2CHRNA7CHRNA4CHRNA5KDM4E | |
| SCHEMBL21522595 | 0.76 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4CHRNA5L3MBTL1 | |
| SCHEMBL2432680 | 0.74 | KDM4E (0.43) | CHRNB2CHRNA7CHRNA4CHRNA5L3MBTL1 | |
| SCHEMBL2434344 | 0.74 | KDM4E (0.43) | CHRNB2CHRNA7CHRNA4CHRNA5L3MBTL1 | |
| SCHEMBL7009532 | 0.74 | KMT2A (0.58) | L3MBTL1KDM4ELMNANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345179-B2 | Process for producing pyrrolidine derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-03-18 | — | — | US | disclosed |
| US-20070105935-A1 | Process for producing pyrrolidine derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-05-10 | — | — | US | disclosed |
| EP-1623975-A1 | PROCESS FOR PRODUCING PYRROLIDINE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105935-A1 | Process for producing pyrrolidine derivative | ACSL4, ALDH18A1, LTA | CHRNB2 4677/4885CHRNA7 4295/4885CHRNA4 1614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.