Sugi Predict

Sugi Predict / Compounds / SCHEMBL4812141

SCHEMBL4812141

SCHEMBL4812141

COC(=O)CCCCCCCCCCC(=O)C[C]=O

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 4/20 0.54
▸ LMNA P02545 3/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ KMT2A Q03164 2/20 0.41
▸ KDM4E B2RXH2 1/20 0.39
▸ RECQL P46063 1/20 0.39
▸ EPHX2 P34913 4/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ HPGD P15428 1/20 0.37
▸ PABPC1 P11940 1/20 0.37
▸ APOBEC3A P31941 1/20 0.37
▸ APOBEC3G Q9HC16 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ POLA1 P09884 1/20 0.37
▸ MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11313358 0.83 TSHR (0.70) TSHRLMNAALDH1A1L3MBTL1KMT2A
SCHEMBL31579008 0.83 TSHR (0.70) TSHRLMNAALDH1A1L3MBTL1KMT2A
SCHEMBL31578856 0.83 TSHR (0.70) TSHRLMNAALDH1A1L3MBTL1KMT2A
SCHEMBL31578944 0.83 TSHR (0.70) TSHRLMNAALDH1A1L3MBTL1KMT2A
Hydrochloric Acid SCHEMBL9033471 0.81 TSHR (0.67) TSHRLMNAALDH1A1L3MBTL1KMT2A
SCHEMBL31578986 0.80 TSHR (0.74) TSHRLMNAALDH1A1L3MBTL1KMT2A
SCHEMBL494299 0.80 TSHR (0.82) TSHRLMNAALDH1A1L3MBTL1KMT2A
SCHEMBL3502791 0.80 TSHR (0.82) TSHRLMNAALDH1A1L3MBTL1KMT2A
SCHEMBL81128 0.80 TSHR (0.82) TSHRLMNAALDH1A1L3MBTL1KMT2A
SCHEMBL118000 0.80 TSHR (0.82) TSHRLMNAALDH1A1L3MBTL1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7371779-B2 Synergistic compositions of N-acylhomoserine lactones and 4-quinolones THE SECRETARY OF STATE FOR DEFENSE SCIENCE AND TECHNOLOGY (GB) 2008-05-13 — — US claimed
US-20050014751-A1 Use of n-acyl homoserine lactones for the treatment of insulitis THE UNIVERSITY OF NOTTINGHAM (GB) 2005-01-20 — — US claimed
US-20040259942-A1 Modulation of stat activity SHAW PETER (GB) 2004-12-23 — — US claimed
EP-1404315-B1 SYNERGISTIC COMPOSITIONS OF N-ACYLHOMOSERINE LACTONES AND 4-QUINOLONES UNIV NOTTINGHAM (GB) 2004-11-03 — — EP claimed
US-20040198978-A1 Synergistic compositions of n-acylhomoserine lactones and 4-quinolones THE SECRETARY OF STATE FOR DEFENCE (GB) 2004-10-07 — — US claimed
EP-1427406-A2 MODULATION OF STAT ACTIVITY University of Nottingham (GB) 2004-06-16 — — EP claimed
EP-1425274-A1 USE OF N-ACYL HOMOSERINE LACTONES FOR THE TREATMENT OF INSULITIS THE UNIVERSITY OF NOTTINGHAM (GB) 2004-06-09 — — EP claimed
EP-1404315-A1 SYNERGISTIC COMPOSITIONS OF N-ACYLHOMOSERINE LACTONES AND 4-QUINOLONES THE UNIVERSITY OF NOTTINGHAM (GB) 2004-04-07 — — EP claimed
US-20030171371-A1 Immunosuppressant n-acyles homoserine lactones THE UNIVERSITY OF NOTTINGHAM (GB) 2003-09-11 — — US claimed
WO-2003026641-A2 MODULATION OF STAT ACTIVITY UNIVERSITY OF NOTTINGHAM (GB) 2003-04-03 — — WO claimed
WO-2003022828-A1 USE OF N-ACYL HOMOSERINE LACTONES FOR THE TREATMENT OF INSULITIS THE UNIVERSITY OF NOTTINGHAM (GB) 2003-03-20 — — WO claimed
WO-2003004017-A1 SYNERGISTIC COMPOSITIONS OF N-ACYLHOMOSERINE LACTONES AND 4-QUINOLONES THE UNIVERSITY OF NOTTINGHAM (GB) 2003-01-16 — — WO claimed
EP-1268459-A1 IMMUNOSUPPRESSANT N-ACYL HOMOSERINE LACTONES THE UNIVERSITY OF NOTTINGHAM (GB) 2003-01-02 — — EP claimed
WO-2001074801-A1 IMMUNOSUPPRESSANT N-ACYLES HOMOSERINE LACTONES UNIVERSITY OF NOTTINGHAM (GB) 2001-10-11 — — WO claimed
US-7371779-B2 Synergistic compositions of N-acylhomoserine lactones and 4-quinolones THE SECRETARY OF STATE FOR DEFENSE SCIENCE AND TECHNOLOGY (GB) 2008-05-13 — — US disclosed
US-20050014751-A1 Use of n-acyl homoserine lactones for the treatment of insulitis THE UNIVERSITY OF NOTTINGHAM (GB) 2005-01-20 — — US disclosed
US-20040259942-A1 Modulation of stat activity SHAW PETER (GB) 2004-12-23 — — US disclosed
US-20030171371-A1 Immunosuppressant n-acyles homoserine lactones THE UNIVERSITY OF NOTTINGHAM (GB) 2003-09-11 — — US disclosed
WO-2003022828-A1 USE OF N-ACYL HOMOSERINE LACTONES FOR THE TREATMENT OF INSULITIS THE UNIVERSITY OF NOTTINGHAM (GB) 2003-03-20 — — WO disclosed
WO-2003004017-A1 SYNERGISTIC COMPOSITIONS OF N-ACYLHOMOSERINE LACTONES AND 4-QUINOLONES THE UNIVERSITY OF NOTTINGHAM (GB) 2003-01-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040259942-A1 Modulation of stat activity STAT3, STAT1, STAT4 TSHR 1308/4885LMNA 4871/4885ALDH1A1 3710/4885
US-20050014751-A1 Use of n-acyl homoserine lactones for the treatment of insulitis HPGDS, CD14, IFNG TSHR 2318/4885LMNA 4597/4885ALDH1A1 3938/4885
US-20030171371-A1 Immunosuppressant n-acyles homoserine lactones MSR1, IL4, SRR TSHR 677/4885LMNA 4831/4885ALDH1A1 3041/4885
US-20040198978-A1 Synergistic compositions of n-acylhomoserine lactones and 4-quinolones CBR3, CBR1, CNR1 TSHR 684/4885LMNA 4068/4885ALDH1A1 2586/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.