Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 11/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4813032 | 0.91 | MAP2K1 (0.35) | KDM4EMEN1MAPTMAPK1KMT2A | |
| SCHEMBL14021454 | 0.83 | KDM4E (0.39) | KDM4EMEN1MAPTMAPK1KMT2A | |
| SCHEMBL4915592 | 0.80 | ALDH1A1 (0.37) | KDM4EMEN1MAPTMAPK1KMT2A | |
| SCHEMBL4748870 | 0.75 | PGR (0.40) | MAPTARCYP11B2PGRCYP2C9 | |
| SCHEMBL4752256 | 0.74 | AR (0.39) | ARCYP11B2PGRKDRMAP2K1 | |
| SCHEMBL4959670 | 0.73 | MRGPRX4 (0.39) | ARPGR | |
| SCHEMBL4114557 | 0.73 | AR (0.37) | ARPGRSLC22A12 | |
| SCHEMBL4978023 | 0.73 | PGR (0.45) | ARPGRSLC22A12 | |
| SCHEMBL4106340 | 0.73 | PGR (0.47) | ARPGRSLC22A12 | |
| SCHEMBL4820235 | 0.71 | PGR (0.39) | KDM4EMEN1MAPTMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135824-A1 | OXYALKYLPYRAZOLE COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2008-11-13 | — | — | WO | disclosed |