Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.47 |
| ▸ | THRA | P10827 | 5/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | TPH1 | P17752 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4890067 | 0.80 | THRB (0.60) | THRBTHRANR3C1PGR | |
| SCHEMBL4818194 | 0.78 | SLC7A5 (0.53) | THRBTHRAPPARGPDCD1CD274 | |
| SCHEMBL29062130 | 0.77 | GRIA1 (0.49) | THRBSLC7A5MEN1KMT2ALMNA | |
| SCHEMBL29062129 | 0.77 | GRIA1 (0.49) | THRBSLC7A5MEN1KMT2ALMNA | |
| SCHEMBL4900953 | 0.74 | KDM4E (0.42) | ACACBLMNAHSD17B10HTR1AALDH1A1 | |
| SCHEMBL4900945 | 0.74 | KDM4E (0.42) | ACACBLMNAHSD17B10HTR1AALDH1A1 | |
| SCHEMBL4809115 | 0.74 | THRB (0.41) | THRBTHRAPPARGPDCD1CD274 | |
| SCHEMBL6553667 | 0.73 | THRB (0.49) | THRBTHRAPPARGPDCD1CD274 | |
| SCHEMBL4812514 | 0.73 | SLC1A5 (0.47) | THRBTHRAPPARGPDCD1CD274 | |
| Hydrochloric Acid SCHEMBL3963272 | 0.72 | THRB (0.59) | THRBTHRAPPARGSLC7A5TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319096-B2 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders II | KARO BIO AB (SE) | 2008-01-15 | — | — | US | claimed |
| US-20040220147-A1 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders ll | KARO BIO AB (SE) | 2004-11-04 | — | — | US | claimed |
| EP-1387825-A1 | THYROID HORMONE RECEPTOR ANTAGONISTS FOR CARDIAC & METABOLIC DISORDERS II | KARO BIO AB (SE) | 2004-02-11 | — | — | EP | claimed |
| WO-2002092550-A1 | THYROID HORMONE RECEPTOR ANTAGONISTS FOR CARDIAC AND METABOLIC DISORDERS II | KARO BIO AB (SE) | 2002-11-21 | — | — | WO | claimed |
| US-7319096-B2 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders II | KARO BIO AB (SE) | 2008-01-15 | — | — | US | disclosed |
| US-20040220147-A1 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders ll | KARO BIO AB (SE) | 2004-11-04 | — | — | US | disclosed |
| EP-1387825-A1 | THYROID HORMONE RECEPTOR ANTAGONISTS FOR CARDIAC & METABOLIC DISORDERS II | KARO BIO AB (SE) | 2004-02-11 | — | — | EP | disclosed |
| WO-2002092550-A1 | THYROID HORMONE RECEPTOR ANTAGONISTS FOR CARDIAC AND METABOLIC DISORDERS II | KARO BIO AB (SE) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220147-A1 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders ll | TSHR, TRHR, THRA | THRB 4/4885THRA 3/4885PPARG 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.