Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29130047 | 0.88 | CYP3A4 (0.33) | CYP3A4TDP1 | |
| SCHEMBL2863077 | 0.88 | CYP3A4 (0.33) | CYP3A4TDP1 | |
| SCHEMBL29395660 | 0.82 | ALDH1A1 (0.40) | CYP3A4TDP1 | |
| SCHEMBL215323 | 0.79 | — | — | |
| SCHEMBL3125569 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL1498089 | 0.78 | ALDH1A1 (0.38) | CYP3A4TDP1 | |
| Fluoride Ion SCHEMBL3891341 | 0.78 | ALDH1A1 (0.39) | CYP3A4TDP1 | |
| SCHEMBL944607 | 0.77 | CYP3A4 (0.33) | CYP3A4TDP1 | |
| SCHEMBL3292756 | 0.77 | ALDH1A1 (0.39) | — | |
| SCHEMBL30572496 | 0.77 | ALDH1A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101492487-A | Process to prepare eplerenone | PHARMACIA & UPJOHN CO LLC (US) | 2009-07-29 | — | — | CN | disclosed |
| CN-100473660-C | Process for preparing eplerenone | UPJOHN CO (US) | 2009-04-01 | — | — | CN | disclosed |
| US-7417140-B2 | 17 beta -Hydroxy-7 alpha -(2'-hydroperoxy-2'-methoxyacetyl)pregna-4,9(11)-dien-3-one-21-carboxylic acid, gamma -lactone chemical intermediate useful to prepare eplerenone a hypotensive agent, useful for treating congestive heart failure | PFIZER INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7414127-B2 | used to prepare eplerenone; intermediates | PFIZER INC. (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1487859-B1 | PROCESS TO PREPARE EPLERENONE | PHARMACIA & UPJOHN CO LLC (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7411062-B2 | 17-Beta -hydroxy-7-alpha-(2'-oxoacetyl or alkanoylcarbonyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, gamma -lactone; intermediate for preparing eplerenone | PFIZER INC. (US) | 2008-08-12 | — | — | US | disclosed |
| EP-1539795-B1 | CRYSTALLINE 17BETA-HYDROXY-7ALPHA-(5'-METHYL-2'-FURYL)-PREGNA-4,9(11)-DIEN-3-ONE-21-CARBOXYLIC ACID, GAMMA-LACTONE | PHARMACIA & UPJOHN CO LLC (US) | 2007-10-31 | — | — | EP | disclosed |
| US-7235655-B2 | Contacting a Delta 3,5-3-enol ether of formula (alkyl enol ether) with a hydride abstractor and an alcohol | PHARMACIA & UPJOHN COMPANY (US) | 2007-06-26 | — | — | US | disclosed |
| US-20070129332-A1 | Processes to prepare eplerenone | PHARMACIA & UPJOHN COMPANY | 2007-06-07 | — | — | US | disclosed |
| US-20070123704-A1 | 17-Beta -hydroxy-7-alpha-(2'-oxoacetyl or alkanoylcarbonyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, gamma -lactone; intermediate for preparing eplerenone | PHARMACIA & UPJOHN COMPANY | 2007-05-31 | — | — | US | disclosed |
| US-20070106072-A1 | 7a-Furyl or thienyl-substituted steroid compounds | PHARMACIA & UPJOHN COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20070100140-A1 | used to prepare eplerenone; intermediates | PHARMACIA & UPJOHN COMPANY | 2007-05-03 | — | — | US | disclosed |
| US-7112670-B2 | intermediates to produce the pharmaceutically useful compound eplerenone | PHARMACIA CORPORATION (US) | 2006-09-26 | — | — | US | disclosed |
| CN-1633445-A | Process for preparing eplerenone | PHARMACIA CORP (US) | 2005-06-29 | — | — | CN | disclosed |
| EP-1539795-A1 | CRYSTALLINE 17BETA-HYDROXY-7ALPHA-(5'-METHYL-2'-FURYL)-PREGNA-4,9(11)-DIEN-3-ONE-21-CARBOXYLIC ACID, GAMMA-LACTONE | Pharmacia & Upjohn Company LLC (US) | 2005-06-15 | — | — | EP | disclosed |
| EP-1487859-A2 | PROCESS TO PREPARE EPLERENONE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-22 | — | — | EP | disclosed |
| US-20040127702-A1 | intermediates to produce the pharmaceutically useful compound eplerenone | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
| WO-2004037844-A1 | CRYSTALLINE 17BETA-HYDROXY-7ALPHA- (5'-METHYL-2'-FURYL)-PREGNA-4,9(11)-DIEN-3-ONE-21-CARBOXYLIC ACID, GAMMA-LACTONE | PHARMACIA & UPJOHN COMPANY (US) | 2004-05-06 | — | — | WO | disclosed |
| US-20030232981-A1 | Contacting a Delta 3,5-3-enol ether of formula (alkyl enol ether) with a hydride abstractor and an alcohol | PHARMACIA & UPJOHN COMPANY | 2003-12-18 | — | — | US | disclosed |
| WO-2003082895-A2 | PROCESS TO PREPARE EPLERENONE | PHARMACIA & UPJOHN COMPANY (US) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070100140-A1 | used to prepare eplerenone; intermediates | CYP11B2, CYP11B1, HSD17B7 | CYP3A4 57/4885TDP1 4790/4885 |
| US-20070123704-A1 | 17-Beta -hydroxy-7-alpha-(2'-oxoacetyl or alkanoylcarbonyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, gamma -lactone; intermediate for preparing eplerenone | HSD17B7, HSD11B1, HSD17B11 | CYP3A4 116/4885TDP1 4866/4885 |
| US-20040127702-A1 | intermediates to produce the pharmaceutically useful compound eplerenone | HSD17B7, CYP11B1, CYP17A1 | CYP3A4 61/4885TDP1 4837/4885 |
| US-20070106072-A1 | 7a-Furyl or thienyl-substituted steroid compounds | NR3C2, HSD17B7, CYP11B1 | CYP3A4 42/4885TDP1 4681/4885 |
| US-20030232981-A1 | Contacting a Delta 3,5-3-enol ether of formula (alkyl enol ether) with a hydride abstractor and an alcohol | NR3C2, HSD3B2, HSD11B2 | CYP3A4 99/4885TDP1 4733/4885 |
| US-20070129332-A1 | Processes to prepare eplerenone | HSD17B7, CYP11B2, CYP4A11 | CYP3A4 37/4885TDP1 4727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.