Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18253192 | 0.83 | ALDH1A1 (0.65) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL7214768 | 0.81 | ALDH1A1 (0.63) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL6276483 | 0.81 | ALDH1A1 (0.57) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL27614825 | 0.79 | ALDH1A1 (0.59) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL547195 | 0.79 | ALDH1A1 (0.59) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL23781564 | 0.77 | ALDH1A1 (0.71) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL3061440 | 0.77 | ALDH1A1 (0.58) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL10162702 | 0.77 | ALDH1A1 (0.71) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL21858115 | 0.77 | ALDH1A1 (0.58) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA | |
| SCHEMBL372200 | 0.77 | ALDH1A1 (1.00) | ALDH1A1CYP1A2ACACBPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365174-B2 | Azalide and azalactam derivatives and method for producing the same | MEIJI SEIKA KAISHA, LTD. (JP) | 2008-04-29 | — | — | US | claimed |
| CN-1984918-A | Ketolide antibacterials | ORTHO MCNEIL PHARM INC (US) | 2007-06-20 | — | — | CN | claimed |
| US-20070042974-A1 | Nozel azalide and azalactam derivatives and method for producing the same | MEIJI SEIKA KAISHA, LTD. (JP) | 2007-02-22 | — | — | US | claimed |
| EP-1661904-A1 | NOVEL AZALIDE AND AZALACTAM DERIVATIVES AND PROCESS FOR THE PRODUCTION OF THE SAME | MEIJI SEIKA KAISHA LTD. (JP) | 2006-05-31 | — | — | EP | claimed |
| EP-1501519-A1 | 9-OXIME MACROLIDE ANTIBACTERIALS | Abbott Laboratories (US) | 2005-02-02 | — | — | EP | claimed |
| US-20040014691-A1 | 9-Oxime macrolide antibacterials | ABBOTT LABORATORIES | 2004-01-22 | — | — | US | claimed |
| WO-2003090761-A1 | 9-OXIME MACROLIDE ANTIBACTERIALS | ABBOTT LABORATORIES (US) | 2003-11-06 | — | — | WO | claimed |
| EP-1345953-A2 | KETOLIDE ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2003-09-24 | — | — | EP | claimed |
| US-6590083-B1 | Compounds of given formula; erythromycin derivatives; useful in the treatment of bacterial and protozoal infections and conditions involving gastric motility | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-07-08 | — | — | US | claimed |
| US-6458771-B1 | SERIES OF KETOLIDE ANTIBACTERIALS IN THE MACROLIDE FAMILY, DRUGS AND INTERMEDIATES, ERYTHROMYCIN ANALOGUES USEFUL IN THE TREATMENT OF BACTERIAL AND PROTOZOAL INFECTIONS AND IN THE TREATMENT OF GASTRIC MOTILITY | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-10-01 | — | — | US | claimed |
| WO-2002032918-A2 | KETOLIDE ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-04-25 | — | — | WO | claimed |
| EP-1171447-A2 | KETOLIDE ANTIBACTERIALS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-01-16 | — | — | EP | claimed |
| WO-2000062783-A2 | KETOLIDE ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-10-26 | — | — | WO | claimed |
| US-7365174-B2 | Azalide and azalactam derivatives and method for producing the same | MEIJI SEIKA KAISHA, LTD. (JP) | 2008-04-29 | — | — | US | disclosed |
| CN-1984918-A | Ketolide antibacterials | ORTHO MCNEIL PHARM INC (US) | 2007-06-20 | — | — | CN | disclosed |
| CN-1310934-C | Erythromycin 6-O-carbamoylketolide derivatives useful as antibacterial agents | ORTHO MCNEIL PHARM INC (US) | 2007-04-18 | — | — | CN | disclosed |
| US-6399582-B1 | GASTROINTESTINAL DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-06-04 | — | — | US | disclosed |
| WO-2002032918-A2 | KETOLIDE ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-04-25 | — | — | WO | disclosed |
| EP-1171447-A2 | KETOLIDE ANTIBACTERIALS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000062783-A2 | KETOLIDE ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014691-A1 | 9-Oxime macrolide antibacterials | CYP2C9, CYP1B1, SULT1E1 | ALDH1A1 946/4885CYP1A2 65/4885ACACB 3878/4885 |
| US-20070042974-A1 | Nozel azalide and azalactam derivatives and method for producing the same | BCL6, NR4A1, NR4A2 | ALDH1A1 1363/4885CYP1A2 583/4885ACACB 2960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.