Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4822465 | 0.89 | PDE2A (0.40) | ALDH1A1ADORA1ADORA3ADORA2AKDM4E | |
| SCHEMBL8807136 | 0.88 | NRP1 (0.41) | ALDH1A1ADORA1ADORA3ADORA2AKDM4E | |
| SCHEMBL8805553 | 0.88 | ALDH1A1 (0.47) | ALOX5ALDH1A1CREBBPADORA1ADORA3 | |
| SCHEMBL8640237 | 0.83 | ALDH1A1 (0.43) | ALOX5ALDH1A1ADORA1ADORA3ADORA2A | |
| SCHEMBL4810493 | 0.81 | MEN1 (0.44) | ALOX5ALDH1A1CREBBPKDM4EHPGD | |
| SCHEMBL7487750 | 0.81 | MAPK1 (0.37) | ALDH1A1ADORA1ADORA3ADORA2AKDM4E | |
| SCHEMBL7958939 | 0.80 | CDK2 (0.38) | ALDH1A1HPGDTSHRMEN1KMT2A | |
| SCHEMBL7490009 | 0.80 | KMT2A (0.38) | ALOX5ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL7496989 | 0.80 | KMT2A (0.38) | ALOX5ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL4818794 | 0.80 | ADORA3 (0.43) | ALDH1A1ADORA1ADORA3ADORA2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329663-B2 | Substituted-triazolopyrimidines as anticancer agents | WYETH (US) | 2008-02-12 | — | — | US | claimed |
| US-20020068744-A1 | Substituted-triazolopyrimidines as anticancer agents | AMERICAN HOME PRODUCTS CORPORATION | 2002-06-06 | — | — | US | claimed |
| JP-5271234-A | — | — | None | — | — | JP | disclosed |
| US-7329663-B2 | Substituted-triazolopyrimidines as anticancer agents | WYETH (US) | 2008-02-12 | — | — | US | disclosed |
| EP-1307200-A2 | SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS | Wyeth (US) | 2003-05-07 | — | — | EP | disclosed |
| US-20020068744-A1 | Substituted-triazolopyrimidines as anticancer agents | AMERICAN HOME PRODUCTS CORPORATION | 2002-06-06 | — | — | US | disclosed |
| WO-2002002563-A2 | SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS | WYETH (US) | 2002-01-10 | — | — | WO | disclosed |
| EP-0550113-B1 | Triazolopyrimidine derivatives with fungicidal activity | SHELL INT RESEARCH (NL) | 1997-10-15 | — | — | EP | disclosed |
| EP-0782997-A2 | Triazolopyrimidine derivatives | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1997-07-09 | — | — | EP | disclosed |
| US-5593996-A | FUNGICIDES | AMERICAN CYANAMID COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| JP-H05271234-A | TRIAZOLOPYRIMIDINE DERIVATIVE | SHELL INTERNATL RES MAATSCHAPPIJ BV | 1993-10-19 | — | — | JP | disclosed |
| EP-0550113-A2 | Triazolopyrimidine derivatives with fungicidal activity | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1993-07-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068744-A1 | Substituted-triazolopyrimidines as anticancer agents | TUBB3, TUBA1C, TUBB1 | ALOX5 4825/4885ALDH1A1 2231/4885CREBBP 850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.