Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14107486 | 0.75 | DPP7 (0.46) | SLC6A9NR1H2NAMPTMAPTESR2 | |
| SCHEMBL20178630 | 0.73 | SLC6A9 (0.40) | SLC6A9KCNH2MEN1KMT2AMAPK1 | |
| SCHEMBL30681483 | 0.73 | GPR119 (0.33) | GPR119STS | |
| SCHEMBL30681271 | 0.72 | MEN1 (0.35) | SLC6A9NR1H2GPR119STSMEN1 | |
| SCHEMBL30585116 | 0.70 | HDAC1 (0.49) | NR1H2NAMPTMAPTESR2GPR119 | |
| SCHEMBL29084829 | 0.70 | HDAC1 (0.49) | NR1H2NAMPTMAPTESR2GPR119 | |
| SCHEMBL18379795 | 0.70 | NR1H2 (0.48) | NR1H2NAMPTMAPTESR2GPR119 | |
| SCHEMBL6204851 | 0.70 | MAPK1 (0.52) | NR1H2NAMPTESR2GPR119HDAC1 | |
| SCHEMBL20178662 | 0.70 | TRPV4 (0.38) | SLC6A9 | |
| SCHEMBL18291623 | 0.69 | NAMPT (0.60) | NR1H2NAMPTMAPTESR2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393844-B2 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7393844-B2 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7393844-B2 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-20060178363-A1 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178363-A1 | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity | CCR1, CCR2, CCR5 | SLC6A9 3714/4885NR1H2 72/4885NAMPT 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.