Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | KDM5A | P29375 | 2/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.41 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 15/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | TET3 | O43151 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31126262 | 0.83 | KDM4E (0.55) | KDM4EKDM5AKDM3AJMJD1CKMO | |
| SCHEMBL87765 | 0.83 | KDM4E (0.55) | KDM4EKDM5AKDM3AJMJD1CKMO | |
| Hydrochloric Acid SCHEMBL21173938 | 0.81 | KDM4E (0.53) | KDM4EKDM5AKDM3AJMJD1CKMO | |
| Bromide SCHEMBL21331919 | 0.81 | KDM4E (0.53) | KDM4EKDM5AKDM3AJMJD1CKMO | |
| Fluoride SCHEMBL21332111 | 0.81 | KDM4E (0.53) | KDM4EKDM5AKDM3AJMJD1CKMO | |
| SCHEMBL2356346 | 0.79 | KMO (0.35) | KMO | |
| 2-Picolinic Acid SCHEMBL3015974 | 0.74 | LMNA (0.67) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL310899 | 0.73 | KDM4E (0.49) | KDM4EKDM5AKDM3AJMJD1CKMO | |
| Quinaldic Acid SCHEMBL27972993 | 0.73 | MGAM (0.68) | KDM4EALOX15TSHRALDH1A1MAPT | |
| SCHEMBL21173946 | 0.72 | P4HA1 (0.47) | KDM4EKDM5AKDM3AJMJD1CKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396835-B2 | Process for the preparation of tubulin inhibitors | WYETH (US) | 2008-07-08 | — | — | US | disclosed |
| EP-1692137-B1 | PROCESS FOR THE PREPARATION OF TUBULIN INHIBITORS | WYETH CORP (US) | 2007-03-07 | — | — | EP | disclosed |
| EP-1692137-A1 | PROCESS FOR THE PREPARATION OF TUBULIN INHIBITORS | Wyeth (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056560-A1 | PROCESS FOR THE PREPARATION OF TUBULIN INHIBITORS | WYETH (US) | 2005-06-23 | — | — | WO | disclosed |
| US-20050124635-A1 | Process for the preparation of tubulin inhibitors | WYETH (US) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124635-A1 | Process for the preparation of tubulin inhibitors | TUBB3, TUBA3C, TUBAL3 | KDM4E 3687/4885KDM5A 2770/4885KDM3A 2274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.