Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 7/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4824732 | 1.00 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3HRH4 | |
| SCHEMBL4828087 | 0.87 | HRH4 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3HRH4 | |
| SCHEMBL4830391 | 0.87 | HRH4 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3HRH4 | |
| SCHEMBL4827538 | 0.81 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4828838 | 0.81 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4819971 | 0.80 | ROCK2 (0.52) | HRH4ROCK2ROCK1CDC42BPB | |
| SCHEMBL4825453 | 0.80 | ROCK2 (0.52) | HRH4ROCK2ROCK1CDC42BPB | |
| SCHEMBL31421618 | 0.78 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4827580 | 0.77 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNB4CHRNA3HRH3 | |
| SCHEMBL4827594 | 0.77 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNB4CHRNA3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | claimed |
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | disclosed |