SCHEMBL4825438

SCHEMBL4825438

C=Cc1c(F)c(F)c(C(=O)O)c(F)c1F

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ METAP2 P50579 1/20 0.32
▸ SMN1; SMN2 Q16637 2/20 0.31
▸ PKM P14618 1/20 0.31
▸ MEN1 O00255 2/20 0.31
▸ KMT2A Q03164 2/20 0.31
▸ CRHBP P24387 1/20 0.31
▸ CRHR2 Q13324 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23609663 0.96 SMN1; SMN2 (0.33) METAP2SMN1; SMN2PKMMEN1KMT2A
SCHEMBL27790465 0.86 — —
SCHEMBL12939148 0.79 ALDH1A1 (0.32) SMN1; SMN2PKM
Formaldehyde SCHEMBL28740243 0.79 MEN1 (0.36) SMN1; SMN2PKMMEN1KMT2ACRHBP
SCHEMBL141037 0.79 CYP1A2 (0.40) SMN1; SMN2PKMMEN1KMT2ACRHBP
Propene SCHEMBL27764142 0.78 MEN1 (0.39) SMN1; SMN2PKMMEN1KMT2ACRHBP
SCHEMBL30693936 0.76 LMNA (0.37) —
Hydrochloric Acid SCHEMBL7881715 0.76 CYP1A2 (0.38) SMN1; SMN2PKMMEN1KMT2ACRHBP
Hydrochloric Acid SCHEMBL4414501 0.76 CYP1A2 (0.38) SMN1; SMN2PKMMEN1KMT2ACRHBP
SCHEMBL203915 0.76 CES2 (0.43) SMN1; SMN2PKMMEN1KMT2ACRHBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1586611-A1 Polymeric dispersants for ink-jet applications Hewlett-Packard Development Company, L.P. (US) 2005-10-19 — — EP claimed
US-20050228071-A1 polymer-dispersed pigment can include a pigment encapsulated with a polymer having hydrophilic and hydrophobic moieties; improved options for bleed control mechanisms and increased reliability of ink-jet architecture HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. 2005-10-13 — — US claimed
US-20160038388-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME LIVING PROOF INC (US) 2016-02-11 — — US disclosed
US-9192553-B2 Hair care compositions and methods of treating hair using same LIVING PROOF, INC. (US) 2015-11-24 — — US disclosed
US-8557223-B2 Hair care compositions and methods of treating hair using same LIVING PROOF, INC. (US) 2013-10-15 — — US disclosed
US-8545818-B2 Hair care compositions and methods of treating hair using same LIVING PROOF, INC. (US) 2013-10-01 — — US disclosed
US-8318138-B2 Hair care compositions and methods of treating hair using same LIVING PROOF, INC. (US) 2012-11-27 — — US disclosed
US-20120251471-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME LIVING PROOF, INC. (US) 2012-10-04 — — US disclosed
US-8226934-B2 controlling frizz in scalp hair by applying a mixture of a nonpolymeric fluorinated ester such as hexafluoroisopropyl 2-fluoroacrylate, water, emulsifiers and flow control agents LIVING PROOF, INC. (US) 2012-07-24 — — US disclosed
US-8226934-B2 controlling frizz in scalp hair by applying a mixture of a nonpolymeric fluorinated ester such as hexafluoroisopropyl 2-fluoroacrylate, water, emulsifiers and flow control agents LIVING PROOF, INC. (US) 2012-07-24 — — US disclosed
US-20110008265-A1 In Situ Polymerization For Hair Treatment LIVING PROOF, INC. (US) 2011-01-13 — — US disclosed
US-20090104136-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME LIVING PROOF, INC. 2009-04-23 — — US disclosed
US-20090104136-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME LIVING PROOF, INC. 2009-04-23 — — US disclosed
WO-2007127065-A9 IN SITU POLYMERIZATION FOR HAIR TREATMENT ANDORA INC (US) 2008-07-31 — — WO disclosed
US-20080066773-A1 IN SITU POLYMERIZATION FOR HAIR TREATMENT LIVING PROOF, INC. 2008-03-20 — — US disclosed
US-7332532-B2 polymer-dispersed pigment can include a pigment encapsulated with a polymer having hydrophilic and hydrophobic moieties; improved options for bleed control mechanisms and increased reliability of ink-jet architecture HEWLETT-PACKARD DEVELOPMENT, L.P. (US) 2008-02-19 — — US disclosed
WO-2007134219-A2 IN SITU POLYMERIZATION FOR SKIN TREATMENT LIVING PROOF, INC. (US) 2007-11-22 — — WO disclosed
WO-2007127065-A2 IN SITU POLYMERIZATION FOR HAIR TREATMENT LIVING PROOF, INC. (US) 2007-11-08 — — WO disclosed
EP-1586611-A1 Polymeric dispersants for ink-jet applications Hewlett-Packard Development Company, L.P. (US) 2005-10-19 — — EP disclosed
US-20050228071-A1 polymer-dispersed pigment can include a pigment encapsulated with a polymer having hydrophilic and hydrophobic moieties; improved options for bleed control mechanisms and increased reliability of ink-jet architecture HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. 2005-10-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080066773-A1 IN SITU POLYMERIZATION FOR HAIR TREATMENT PPOX, SUCLG1, GFER METAP2 2157/4885SMN1; SMN2 4508/4885PKM 2201/4885
US-20120251471-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME TET1, TET2, TET3 METAP2 2650/4885SMN1; SMN2 4702/4885PKM 4226/4885
US-20110008265-A1 In Situ Polymerization For Hair Treatment PPOX, SUCLG1, GFER METAP2 2198/4885SMN1; SMN2 4508/4885PKM 2287/4885
US-20090104136-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME TET1, TET2, TET3 METAP2 2650/4885SMN1; SMN2 4702/4885PKM 4226/4885
US-20160038388-A1 HAIR CARE COMPOSITIONS AND METHODS OF TREATING HAIR USING SAME TET1, TET2, TET3 METAP2 2650/4885SMN1; SMN2 4702/4885PKM 4226/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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