Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953694 | 0.88 | LIPE (0.38) | GRM4SMN1; SMN2ALDH1A1NPC1HSD17B10 | |
| SCHEMBL4837047 | 0.77 | NPC1 (0.36) | ALDH1A1NPC1KMT2AMEN1 | |
| SCHEMBL4828449 | 0.76 | SPR (0.34) | HPGD | |
| SCHEMBL16242493 | 0.74 | FAAH (0.42) | SMN1; SMN2ALDH1A1NPC1TSHRKMT2A | |
| SCHEMBL2955527 | 0.72 | GAA (0.43) | SMN1; SMN2ALDH1A1NPC1HSD17B10HPGD | |
| SCHEMBL1573644 | 0.70 | RAB9A (0.39) | SMN1; SMN2ALDH1A1NPC1HSD17B10HPGD | |
| SCHEMBL2965248 | 0.68 | NPC1 (0.36) | SMN1; SMN2ALDH1A1NPC1HPGDKMT2A | |
| SCHEMBL2956860 | 0.67 | SPR (0.36) | — | |
| SCHEMBL1573729 | 0.66 | HDAC1 (0.39) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL16242496 | 0.66 | SPR (0.32) | SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937648-B1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI SA (FR) | 2014-11-26 | — | — | EP | disclosed |
| EP-1937648-A1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | sanofi-aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042178-A1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-04-19 | — | — | WO | disclosed |