Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12924164 | 0.88 | TSHR (0.60) | ALDH1A1LMNATSHRMAPTMEN1 | |
| SCHEMBL989106 | 0.87 | ATM (0.46) | CASP6HCAR3ALDH1A1LMNATSHR | |
| SCHEMBL18153017 | 0.87 | MAPT (0.48) | CASP6HCAR3ALDH1A1LMNATSHR | |
| SCHEMBL4435755 | 0.87 | HCAR3 (0.67) | HCAR3ALDH1A1LMNAVCAM1MAPT | |
| SCHEMBL5315134 | 0.87 | ALDH1A1 (0.55) | ALDH1A1LMNATSHRCYP3A4MAPT | |
| SCHEMBL14561020 | 0.87 | LMNA (0.59) | HCAR3ALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL5777374 | 0.87 | ITGB1 (0.49) | CASP6HCAR3ALDH1A1LMNATSHR | |
| SCHEMBL29197082 | 0.85 | DTYMK (0.49) | CASP6HCAR3ALDH1A1LMNATSHR | |
| SCHEMBL14561019 | 0.84 | ERN1 (0.48) | HCAR3ALDH1A1LMNATSHRVCAM1 | |
| SCHEMBL31548076 | 0.84 | SIRT6 (0.49) | HCAR3ALDH1A1LMNAVCAM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9492554-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| US-9492554-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160263231-A1 | Methods and Compositions Related to Viral Inhibition | CLEMSON UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-20160263231-A1 | Methods and Compositions Related to Viral Inhibition | CLEMSON UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2016-08-11 | — | — | US | disclosed |
| US-9072761-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2015-07-07 | — | — | US | disclosed |
| US-9072761-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2015-07-07 | — | — | US | disclosed |
| US-20110046982-A1 | METHODS AND COMPOSITIONS RELATED TO VIRAL INHIBITION | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046982-A1 | METHODS AND COMPOSITIONS RELATED TO VIRAL INHIBITION | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2011-02-24 | — | — | US | disclosed |
| US-7320995-B2 | Benzimidazoles and benzothiazoles as inhibitors of map kinase | ELI LILLY AND COMPANY (US) | 2008-01-22 | — | — | US | disclosed |
| US-7320995-B2 | Benzimidazoles and benzothiazoles as inhibitors of map kinase | ELI LILLY AND COMPANY (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |
| US-20050272791-A1 | Benzimidazoles and benzothiazoles as inhibitors of map kinase | EIL LILLY AND COMPANY (US) | 2005-12-08 | — | — | US | disclosed |
| EP-1554272-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004014900-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272791-A1 | Benzimidazoles and benzothiazoles as inhibitors of map kinase | MAP3K8, MAPK8, MAPK1 | CASP6 1796/4885HCAR3 3873/4885ALDH1A1 1864/4885 |
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | TOP1, TOP2B, TOP2A | CASP6 1068/4885HCAR3 3753/4885ALDH1A1 3784/4885 |
| US-20160263231-A1 | Methods and Compositions Related to Viral Inhibition | EIF2AK2, NSUN2, NSUN3 | CASP6 2024/4885HCAR3 4368/4885ALDH1A1 4399/4885 |
| US-20110046982-A1 | METHODS AND COMPOSITIONS RELATED TO VIRAL INHIBITION | EIF2AK2, NSUN2, NSUN3 | CASP6 2024/4885HCAR3 4368/4885ALDH1A1 4399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.