Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923385 | 0.83 | ALPL (0.45) | ALDH1A1HPGDNPSR1SMN1; SMN2PARP1 | |
| SCHEMBL4843555 | 0.82 | TSPO (0.63) | TSPOCYP2C19 | |
| SCHEMBL6256479 | 0.79 | TSPO (0.71) | TSPOALDH1A1SMN1; SMN2MAPK8MAPT | |
| SCHEMBL8959269 | 0.76 | TSPO (0.48) | TSPOALDH1A1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL5746061 | 0.75 | TSPO (0.60) | TSPOCYP3A4 | |
| Hydrochloric Acid SCHEMBL4839588 | 0.75 | TSPO (0.59) | TSPOCYP3A4 | |
| SCHEMBL5788409 | 0.74 | TSPO (0.44) | TSPOCYP2C19 | |
| SCHEMBL3926531 | 0.72 | TSPO (0.46) | TSPOCYP2C19ALPL | |
| SCHEMBL5747445 | 0.72 | TSPO (0.61) | TSPOALDH1A1HPGDNPSR1KDM4E | |
| SCHEMBL3930905 | 0.71 | POLB (0.48) | TSPOALDH1A1HPGDKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255129-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-10-16 | — | — | US | disclosed |
| US-7405306-B2 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-07-29 | — | — | US | disclosed |
| US-20080076775-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-03-27 | — | — | US | disclosed |
| US-7323467-B2 | 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-01-29 | — | — | US | disclosed |
| US-20070219202-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5 b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2007-09-20 | — | — | US | disclosed |
| EP-1492792-B1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO¬4,5-B|INDOLE-1-ACETAMIDE DERIVATIVES, PREPARATION AND USE THEREOF IN MEDICAMENTS | SANOFI AVENTIS (FR) | 2006-03-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076775-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | IDO1, IDO2, TPH1 | TSPO 1596/4885ALDH1A1 60/4885HPGD 780/4885 |
| US-20070219202-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5 b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | IDO1, IDO2, TPH1 | TSPO 1814/4885ALDH1A1 68/4885HPGD 987/4885 |
| US-20080255129-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | IDO1, IDO2, TPH1 | TSPO 1596/4885ALDH1A1 60/4885HPGD 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.