Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15611386 | 0.94 | NPSR1 (0.40) | NPSR1ALDH1A1HTTNPC1POLB | |
| SCHEMBL2394240 | 0.84 | NPSR1 (0.43) | NPSR1ALDH1A1HTTNPC1POLB | |
| SCHEMBL2866274 | 0.83 | NPSR1 (0.41) | NPSR1ALDH1A1HTTNPC1POLB | |
| SCHEMBL11011944 | 0.83 | NPSR1 (0.41) | NPSR1ALDH1A1HTTNPC1POLB | |
| SCHEMBL4560019 | 0.81 | L3MBTL1 (0.46) | NPSR1ALDH1A1RAB9AKMT2ATSHR | |
| SCHEMBL3664780 | 0.79 | NPSR1 (0.46) | NPSR1ALDH1A1HTTNPC1POLB | |
| SCHEMBL17923422 | 0.78 | ALDH1A1 (0.40) | NPSR1ALDH1A1HTTNPC1POLB | |
| SCHEMBL4732140 | 0.77 | NPSR1 (0.44) | NPSR1ALDH1A1HTTNPC1POLB | |
| SCHEMBL11376555 | 0.74 | NPSR1 (0.41) | NPSR1ALDH1A1HTTNPC1POLB | |
| SCHEMBL3799516 | 0.74 | L3MBTL1 (0.36) | NPSR1ALDH1A1NPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411057-A2 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | Siemens Medical Solutions USA, Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111303-A2 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-09-30 | — | — | WO | disclosed |