Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 3/20 | 0.49 |
| ▸ | KIF11 | P52732 | 6/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.45 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.45 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838885 | 1.00 | BHMT (0.49) | BHMTKIF11SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL23879883 | 0.86 | GSR (0.52) | BHMTSLC1A2SLC1A1SLC1A3GRIK1 | |
| SCHEMBL5281759 | 0.83 | BHMT (0.49) | BHMTKIF11SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL18894223 | 0.83 | BHMT (0.49) | BHMTKIF11SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL5697661 | 0.80 | KIF11 (0.50) | BHMTKIF11SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL8418914 | 0.80 | KIF11 (0.50) | BHMTKIF11SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL14420362 | 0.80 | KIF11 (0.50) | BHMTKIF11SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL19734386 | 0.79 | BHMT (0.45) | BHMTKIF11SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL8260017 | 0.79 | CA1 (0.39) | BHMTKIF11SLC1A1GRIN2DGRIN3B | |
| SCHEMBL7376089 | 0.78 | SLC1A2 (0.43) | BHMTKIF11SLC1A2SLC1A1SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465745-B2 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |
| CN-100400511-C | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMA (US) | 2008-07-09 | — | — | CN | disclosed |
| US-7326719-B2 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| CN-1761652-A | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMA (US) | 2006-04-19 | — | — | CN | disclosed |
| EP-1606258-A1 | CATHEPSIN S INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-12-21 | — | — | EP | disclosed |
| US-20050222145-A1 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-10-06 | — | — | US | disclosed |
| WO-2004083182-A1 | CATHEPSIN S INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-09-30 | — | — | WO | disclosed |
| US-20040180886-A1 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180886-A1 | Cathepsin S inhibitors | CTSS, CTSB, CTSZ | BHMT 2145/4885KIF11 4360/4885SLC1A2 3186/4885 |
| US-20050222145-A1 | Cathepsin S inhibitors | CTSS, CTSB, CTSZ | BHMT 2207/4885KIF11 4310/4885SLC1A2 3131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.