Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870685 | 0.82 | OPRD1 (0.62) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| SCHEMBL5870682 | 0.82 | OPRD1 (0.62) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| SCHEMBL5870753 | 0.82 | OPRD1 (0.62) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| SCHEMBL14067865 | 0.79 | OPRM1 (0.51) | OPRM1KMT2AALDH1A1 | |
| SCHEMBL5870834 | 0.79 | OPRM1 (0.55) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| SCHEMBL5870832 | 0.79 | OPRM1 (0.55) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| SCHEMBL5870870 | 0.79 | OPRM1 (0.52) | OPRM1OPRD1OPRK1KCNH2SIGMAR1 | |
| SCHEMBL5870944 | 0.77 | OPRM1 (0.50) | OPRM1OPRD1OPRK1CHRM1CHRM3 | |
| SCHEMBL5870718 | 0.76 | ACHE (0.64) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| SCHEMBL21636271 | 0.76 | KMT2A (0.53) | SLC6A3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234247-A1 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| US-20080234247-A1 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| US-20080234247-A1 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| US-7361666-B2 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR, INC. (US) | 2008-04-22 | — | — | US | disclosed |
| US-7361666-B2 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR, INC. (US) | 2008-04-22 | — | — | US | disclosed |
| US-7361666-B2 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR, INC. (US) | 2008-04-22 | — | — | US | disclosed |
| US-20030069418-A1 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR, INC. | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069418-A1 | Heterocyclic analgesic compounds and methods of use thereof | OPRL1, TRPV1, OPRK1 | OPRM1 4/4885OPRD1 9/4885OPRK1 3/4885 |
| US-20080234247-A1 | Heterocyclic analgesic compounds and methods of use thereof | OPRL1, TRPV1, OPRK1 | OPRM1 4/4885OPRD1 9/4885OPRK1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.