Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871033 | 0.84 | OPRD1 (0.44) | OPRM1SLC6A2SLC6A4OPRD1L3MBTL1 | |
| SCHEMBL7498243 | 0.84 | OPRD1 (0.44) | OPRM1SLC6A2SLC6A4OPRD1L3MBTL1 | |
| SCHEMBL7503837 | 0.84 | OPRD1 (0.44) | OPRM1SLC6A2SLC6A4OPRD1L3MBTL1 | |
| SCHEMBL5870837 | 0.81 | OPRM1 (0.40) | OPRM1SLC6A2SLC6A4OPRD1L3MBTL1 | |
| SCHEMBL7497822 | 0.81 | OPRM1 (0.40) | OPRM1SLC6A2SLC6A4OPRD1L3MBTL1 | |
| SCHEMBL7498252 | 0.80 | OPRM1 (0.39) | OPRM1SLC6A2SLC6A4OPRD1 | |
| SCHEMBL5870866 | 0.79 | OPRM1 (0.41) | OPRM1SLC6A2SLC6A4OPRD1SLC6A3 | |
| SCHEMBL7501264 | 0.78 | OPRD1 (0.42) | OPRM1OPRD1L3MBTL1SLC6A3KCNH2 | |
| SCHEMBL7497373 | 0.78 | SLC6A2 (0.41) | OPRM1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL5870992 | 0.78 | OPRD1 (0.39) | OPRM1SLC6A2SLC6A4OPRD1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234247-A1 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| US-7361666-B2 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR, INC. (US) | 2008-04-22 | — | — | US | disclosed |
| US-20030069418-A1 | Heterocyclic analgesic compounds and methods of use thereof | SEPRACOR, INC. | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069418-A1 | Heterocyclic analgesic compounds and methods of use thereof | OPRL1, TRPV1, OPRK1 | OPRM1 4/4885SLC6A2 540/4885SLC6A4 448/4885 |
| US-20080234247-A1 | Heterocyclic analgesic compounds and methods of use thereof | OPRL1, TRPV1, OPRK1 | OPRM1 4/4885SLC6A2 540/4885SLC6A4 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.