SCHEMBL4839367

SCHEMBL4839367

ClCc1cccc(CC[Si](Cl)(Cl)Cl)c1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.40
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
TAAR1 Q96RJ0 7/20 0.35
NOS1 P29475 2/20 0.33
NOS2 P35228 2/20 0.33
CYP2D6 P10635 1/20 0.33
NOS3 P29474 1/20 0.33
MAOA P21397 2/20 0.32
MAOB P27338 2/20 0.32
LMNA P02545 1/20 0.32
CYP19A1 P11511 1/20 0.31
DRD2 P14416 1/20 0.31
DRD1 P21728 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4844564 0.84 TSHR (0.38) TSHRMEN1KMT2ATAAR1NOS1
SCHEMBL4850067 0.84 TSHR (0.38) TSHRMEN1KMT2ATAAR1NOS1
SCHEMBL9311601 0.82 TSHR (0.48) TSHRMEN1KMT2ATAAR1NOS1
SCHEMBL5486678 0.79 TAAR1 (0.59) MEN1KMT2ATAAR1
SCHEMBL225197 0.79 TSHR (0.54) TSHRMEN1KMT2ATAAR1NOS1
SCHEMBL28065354 0.78 TDP1 (0.52) TSHRMEN1KMT2ATAAR1NOS1
SCHEMBL28326229 0.78 TSHR (0.45) TSHRMEN1KMT2ATAAR1NOS1
SCHEMBL926567 0.78 CA2 (0.37) TAAR1
SCHEMBL33722031 0.78 TSHR (0.45) TSHRMEN1KMT2ATAAR1NOS1
SCHEMBL5488915 0.78 TAAR1 (0.57) TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120232255-A1 PRETREATMENT CARTRIDGE FOR SEPARATING SUBSTANCE AND METHOD OF PRETREATMENT USING THE SAME TERUO OKANO (JP) 2012-09-13 US disclosed
EP-2474827-A1 PRETREATMENT CARTRIDGE FOR SEPARATING SUBSTANCE AND METHOD OF PRETREATMENT USING SAME CellSeed Inc. (JP) 2012-07-11 EP disclosed
EP-2471899-A1 TEMPERATURE-RESPONSIVE CELL CULTURE SUBSTRATE ON WHICH A STRAIGHT-CHAIN TEMPERATURE-RESPONSIVE POLYMER IS IMMOBILIZED, AND MANUFACTURING METHOD THEREFOR Tokyo Women's Medical University (JP) 2012-07-04 EP disclosed
US-20120156781-A1 TEMPERATURE-RESPONSIVE CELL CULTURE SUBSTRATE ON WHICH A STRAIGHT-CHAIN TEMPERATURE-RESPONSIVE POLYMER IS IMMOBILIZED, AND MANUFACTURING METHOD THEREFOR TOKYO WOMEN'S MEDICAL UNIVERSITY (JP) 2012-06-21 US disclosed
US-7463400-B1 Electrochromic display device FUJI XEROX CO., LTD. (JP) 2008-12-09 US disclosed
US-6284365-B1 FOR CONTROLLING PHYSICAL PROPERTIES OF SURFACE AND INTERFACE OF SOLID ARTICLE SUCH AS WETTABILITY, ADHESIVE PROPERTY, SURFACE ENERGY, DISPERSABILITY, CHEMICAL RESISTANCE FUJI XEROX CO., LTD. (JP) 2001-09-04 US disclosed