Sugi Predict

Sugi Predict / Compounds / SCHEMBL484011

SCHEMBL484011

SCHEMBL484011

NC1CCCN1c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.44
▸ USP30 Q70CQ3 1/20 0.40
▸ MBTD1 Q05BQ5 1/20 0.40
▸ L3MBTL3 Q96JM7 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ MAPT P10636 4/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39
▸ FFAR1 O14842 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ NOS1 P29475 1/20 0.38
▸ SLC18A3 Q16572 2/20 0.37
▸ CHRNB2 P17787 1/20 0.37
▸ CHRNB4 P30926 1/20 0.37
▸ CHRNA3 P32297 1/20 0.37
▸ CHRNA7 P36544 1/20 0.37
▸ CHRNA4 P43681 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ MEN1 O00255 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2926923 0.94 MBTD1 (0.43) KMT2AUSP30MBTD1L3MBTL3L3MBTL1
SCHEMBL905238 0.78 CHRNB2 (0.47) MAPTCHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL1238918 0.77 HRH3 (0.46) MAPTSMN1; SMN2KDM4EALDH1A1
SCHEMBL28795066 0.75 KMT2A (0.44) KMT2AUSP30MBTD1L3MBTL3L3MBTL1
SCHEMBL8526124 0.75 KMT2A (0.44) KMT2AUSP30MBTD1L3MBTL3L3MBTL1
SCHEMBL23064524 0.75 KMT2A (0.44) KMT2AUSP30MBTD1L3MBTL3L3MBTL1
SCHEMBL3535701 0.75 MAOA (0.54) KMT2AMBTD1L3MBTL3L3MBTL1MAPT
SCHEMBL8502504 0.75 L3MBTL1 (0.44) KMT2AMBTD1L3MBTL3L3MBTL1MAPT
SCHEMBL15515642 0.75 KMT2A (0.44) KMT2AUSP30MBTD1L3MBTL3L3MBTL1
SCHEMBL8284787 0.75 MAOA (0.54) KMT2AMBTD1L3MBTL3L3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3638200-A1 PROCESS FOR DYEING KERATIN MATERIALS USING AT LEAST ONE BLUE, PURPLE OR GREEN DYE AND AT LEAST ONE DISULFIDE, THIOL OR PROTECTED THIOL FLUORESCENT DYE L'Oreal (FR) 2020-04-22 — — EP claimed
US-9980893-B2 Dye composition comprising a 1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-amine compound L'OREAL (FR) 2018-05-29 — — US disclosed
CN-106999395-A Dye composite comprising p-phenylenediamine fouramine and specific coupling agent 莱雅公司 2017-08-01 — — CN disclosed
CN-103998531-B Three aromatic azo methine direct dyess, dye composite, implementation and the purposes for including at least one such dyestuff 欧莱雅 2017-07-28 — — CN disclosed
WO-2017021511-A1 KIT FOR DYEING AND/OR BLEACHING KERATIN FIBERS COMPRISING AN ALKALINE AGENT, AN OXIDIZING AGENT, AND AN OPENABLE AND CLOSABLE AIRTIGHT CONTAINER L'OREAL (FR) 2017-02-09 — — WO disclosed
EP-3102574-A1 DYE COMPOSITION COMPRISING A 1,2,3,4-TETRAHYDROPYRIDO[2,3-B]PYRAZIN-7-AMINE COMPOUND L'Oréal (FR) 2016-12-14 — — EP disclosed
US-20160303018-A1 DYE COMPOSITION COMPRISING A 1,2,3,4-TETRAHYDROPYRIDO[2,3-B]PYRAZIN-7-AMINE COMPOUND L'OREAL (FR) 2016-10-20 — — US disclosed
EP-2248515-B1 Use for dying keratinic fibers of a azomethine-type compound having a pyrazolopyridine group ORÉAL L (FR) 2015-12-23 — — EP disclosed
WO-2015092011-A1 DYE COMPOSITION COMPRISING A 1,2,3,4-TETRAHYDROPYRIDO[2,3-B]PYRAZIN-7-AMINE COMPOUND L'OREAL (FR) 2015-06-25 — — WO disclosed
EP-2246038-B1 Azomethinic cationic pyrazolidine derivatives for dyeing keratin fiber ORÉAL L (FR) 2014-10-22 — — EP disclosed
EP-1298135-A1 Dyeing composition containing silyl substituted p-aminophenol or p-phenylenediamine L'OREAL (FR) 2003-04-02 — — EP disclosed
EP-1297819-A2 Composition for dyeing keratinous fibres comprising a cationic azo dye L'OREAL (FR) 2003-04-02 — — EP disclosed
WO-2002080869-A2 NOVEL DYEING COMPOSITION FOR DYEING KERATINOUS FIBRES COMPRISING A PARTICULAR DICATIONIC MONOAZO DYE L'OREAL (FR) 2002-10-17 — — WO disclosed
WO-2002078658-A1 DYEING COMPOSITION FOR DYEING KERATINOUS FIBRES COMPRISING A CATIONIC AZO-DYE L'OREAL (FR) 2002-10-10 — — WO disclosed
WO-2002078660-A1 DYEING COMPOSITION FOR DYEING KERATINOUS FIBRES COMPRISING A CATIONIC AZO-DYE L'OREAL (FR) 2002-10-10 — — WO disclosed
WO-2002078659-A1 DYEING COMPOSITION FOR DYEING KERATINOUS FIBRES COMPRISING A CATIONIC AZO-DYE L'OREAL (FR) 2002-10-10 — — WO disclosed
WO-2002078596-A2 NOVEL DYEING COMPOSITION FOR DYEING KERATINOUS FIBRES COMPRISING A PARTICULAR DICATIONIC DIAZO DYE L'OREAL (FR) 2002-10-10 — — WO disclosed
WO-2002078657-A1 DYEING COMPOSITION FOR DYEING KERATINOUS FIBRES COMPRISING A CATIONIC AZO-DYE L'OREAL (FR) 2002-10-10 — — WO disclosed
WO-2002076417-A1 OXIDATION DYEING COMPOSITION CONTAINING AT LEAST ONE 3-AMINO PYRAZOLO-[1,5-A]-PYRIDINE OXIDATION BASE AND AT LEAST ONE PARTICULAR PYRAZOLOTRIAZOLE COUPLING AGENT L'OREAL (FR) 2002-10-03 — — WO disclosed
WO-2002076418-A1 OXIDATION DYEING COMPOSITION 3-AMINO PYRAZOLO-[1,5-A]-PYRIDINE AND ONE PYRAZOLOTRIAZOLE COUPLING AGENT L'OREAL (FR) 2002-10-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160303018-A1 DYE COMPOSITION COMPRISING A 1,2,3,4-TETRAHYDROPYRIDO[2,3-B]PYRAZIN-7-AMINE COMPOUND CBR3, AOC3, NOX3 KMT2A 4580/4885USP30 3934/4885MBTD1 3916/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.