Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CDC25B | P30305 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 4/20 | 0.45 |
| ▸ | ERN1 | O75460 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29446582 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EALDH1A1HPGDBACE1 | |
| SCHEMBL29446584 | 0.78 | PTPN1 (0.44) | KDM4EERN1AKR1C3AKR1C2 | |
| SCHEMBL548518 | 0.78 | PTPN1 (0.46) | KDM4EALDH1A1ERN1POLBFABP3 | |
| SCHEMBL6701301 | 0.76 | SMN1; SMN2 (0.63) | SMN1; SMN2HDAC8KDM4EALDH1A1HPGD | |
| SCHEMBL5342329 | 0.76 | SMN1; SMN2 (0.84) | SMN1; SMN2KDM4EALDH1A1HPGDBACE1 | |
| SCHEMBL5196747 | 0.76 | ERN1 (0.62) | SMN1; SMN2CDC25BKDM4EALDH1A1HPGD | |
| SCHEMBL4845911 | 0.76 | ERN1 (0.62) | SMN1; SMN2KDM4EALDH1A1HPGDERN1 | |
| SCHEMBL27783382 | 0.76 | FABP3 (0.53) | SMN1; SMN2CDC25BKDM4EALDH1A1HPGD | |
| SCHEMBL5268526 | 0.73 | HNF4A (0.59) | SMN1; SMN2CDC25BKDM4EALDH1A1HPGD | |
| Acrylic Acid SCHEMBL27869593 | 0.72 | SMN1; SMN2 (0.54) | SMN1; SMN2HDAC8KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423030-B2 | 1-amino-phthalazine derivatives, the preparation and the therapeutic use thereof | SANOFI-AVENTIS (FR) | 2008-09-09 | — | — | US | disclosed |
| US-20070099895-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099895-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | CYP11B2, CYP11B1, GOT2 | SMN1; SMN2 1239/4885CDC25B 1156/4885HDAC8 647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.