Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17959424 | 0.91 | ALOX15 (0.47) | ALOX15ALDH1A1TSHRHSD17B10CYP1A2 | |
| SCHEMBL5746650 | 0.86 | MAPK8 (0.45) | MCL1MAPK8MAPK9OXER1 | |
| SCHEMBL4843888 | 0.85 | GAA (0.43) | ALOX15ALDH1A1TSHRHSD17B10CYP1A2 | |
| SCHEMBL17974081 | 0.83 | ALOX15 (0.44) | ALOX15ALDH1A1TSHRHSD17B10CYP1A2 | |
| SCHEMBL5702463 | 0.78 | ALOX15 (0.47) | ALOX15ALDH1A1TSHRHSD17B10CYP1A2 | |
| SCHEMBL3923885 | 0.78 | ALOX15 (0.47) | ALOX15ALDH1A1TSHRHSD17B10CYP1A2 | |
| SCHEMBL4840274 | 0.76 | MAPK8 (0.40) | ALDH1A1TSHRHSD17B10LMNAHPGD | |
| SCHEMBL2085240 | 0.75 | KMT2A (0.48) | ALOX15ALDH1A1TSHRHSD17B10CYP1A2 | |
| SCHEMBL24482981 | 0.74 | MAPK8 (0.44) | ALOX15ALDH1A1TSHRHSD17B10CYP1A2 | |
| SCHEMBL3896643 | 0.73 | ALDH1A1 (0.51) | ALOX15ALDH1A1TSHRHSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100543016-C | Intermediate compounds of 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino [4, 5-b ] indole-1-acetamide derivatives | SANOFI AVENTIS (FR) | 2009-09-23 | — | — | CN | disclosed |
| US-20080255129-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-10-16 | — | — | US | disclosed |
| CN-100406459-C | 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino [4, 5-b ] indole-1-acetamide derivatives, their preparation and use in therapy | SANOFI AVENTIS (FR) | 2008-07-30 | — | — | CN | disclosed |
| US-7405306-B2 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-07-29 | — | — | US | disclosed |
| US-20080076775-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-03-27 | — | — | US | disclosed |
| US-7323467-B2 | 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2008-01-29 | — | — | US | disclosed |
| US-20070219202-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5 b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | SANOFI-AVENTIS (FR) | 2007-09-20 | — | — | US | disclosed |
| US-7235554-B2 | 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments | SANOFI-AVENTIS (FR) | 2007-06-26 | — | — | US | disclosed |
| CN-1970538-A | Intermediate compounds of 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino [4, 5-b ] indole-1-acetamide derivatives | SANOFI AVENTIS (FR) | 2007-05-30 | — | — | CN | disclosed |
| CN-1656099-A | 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino [4, 5-b ] indole-1-acetamide derivatives, their preparation and use in therapy | SANOFI AVENTIS (FR) | 2005-08-17 | — | — | CN | disclosed |
| US-20050124615-A1 | 3-heteroarly-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments | SANOFI (FR) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076775-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | IDO1, IDO2, TPH1 | ALOX15 828/4885ALDH1A1 60/4885TSHR 891/4885 |
| US-20050124615-A1 | 3-heteroarly-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments | HRH4, IDO1, HTR4 | ALOX15 808/4885ALDH1A1 1008/4885TSHR 2876/4885 |
| US-20070219202-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5 b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | IDO1, IDO2, TPH1 | ALOX15 1011/4885ALDH1A1 68/4885TSHR 780/4885 |
| US-20080255129-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics | IDO1, IDO2, TPH1 | ALOX15 828/4885ALDH1A1 60/4885TSHR 891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.